牛晶状体中白三烯B4的生物合成。
Biosynthesis of leukotriene B4 in bovine lens.
作者信息
Fujiwara H, Nakata K
机构信息
Department of Ophthalmology, Kawasaki Medical School, Okayama.
出版信息
Jpn J Ophthalmol. 1988;32(1):44-50.
Ocular allergic reactions and inflammatory cascades in the eye involve various arachidonic acid metabolites. One such metabolite, leukotriene B4 (LTB4) was detected in bovine lenses after incubation in Tyrode's solution and analyzed by reverse phase and normal phase high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). LTB4, a product of the lipoxygenase pathway has a chemotactic potency, and may play an important role in the inflammatory cascade. Our results demonstrate the capacity of the bovine lens to synthesize LTB4. It is possible that LTB4 synthesized in lenses under some conditions plays an important role in ocular inflammatory and allergic reactions.
眼部的过敏反应和炎症级联反应涉及多种花生四烯酸代谢产物。其中一种代谢产物白三烯B4（LTB4），在牛晶状体于Tyrode溶液中孵育后被检测到，并通过反相和正相高效液相色谱（HPLC）以及气相色谱-质谱联用（GC-MS）进行分析。LTB4是脂氧合酶途径的产物，具有趋化活性，可能在炎症级联反应中起重要作用。我们的结果证明了牛晶状体合成LTB4的能力。在某些条件下晶状体中合成的LTB4有可能在眼部炎症和过敏反应中发挥重要作用。
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