利用光氧化还原催化在未保护的单糖中进行位点选择性碳-碳键形成。
Site-selective carbon-carbon bond formation in unprotected monosaccharides using photoredox catalysis.
作者信息
Wan Ieng Chim Steven, Witte Martin D, Minnaard Adriaan J
机构信息
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
出版信息
Chem Commun (Camb). 2017 May 2;53(36):4926-4929. doi: 10.1039/c7cc01416c.
PMID:28425550
Abstract
Site-selective photoredox reactions with somophiles readily enable branching of the carbon skeleton of unprotected glucosides, allosides, and xylosides regioselectively at C3. These reactions open the possibility of selective C-C bond formation in monosaccharides without multi-step protection-deprotection strategies.
摘要
与嗜糖体进行的位点选择性光氧化还原反应能够轻松地使未受保护的葡萄糖苷、阿洛糖苷和木糖苷的碳骨架在C3位置区域选择性地发生支化。这些反应为在单糖中形成选择性C-C键开辟了可能性，而无需多步保护-脱保护策略。
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