源自2,6-（吡啶基）亚氨基二金刚烷的五配位和六配位银（I）配合物：生物活性银对细菌根除的持续释放
Five- and Six-Coordinated Silver(I) Complexes Derived from 2,6-(Pyridyl)iminodiadamantanes: Sustained Release of Bioactive Silver toward Bacterial Eradication.
作者信息
Jimenez Jorge, Chakraborty Indranil, Del Cid Anthony M, Mascharak Pradip K
机构信息
Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
出版信息
Inorg Chem. 2017 May 1;56(9):4784-4787. doi: 10.1021/acs.inorgchem.7b00621. Epub 2017 Apr 20.
Silver(I) complexes of two designed tridentate ligands, namely, 2,6-(pyridyl)iminoditriazaadamantane (pydTAm) and 2,6-(pyridyl)iminodiadamantane (pydAm), have been synthesized and structurally characterized. Ag(pydTAm) (1), the hitherto unknown mer isomer of a silver(I) octahedral complex, crystallizes in a highly symmetric body-centered cubic I4̅3m space group. Quite in contrast, the Ag center in the analogous Ag(pydAm) (2) complex resides in a trigonal-bipyramidal geometry and crystallizes in a triclinic P1̅ space group with two crystallographically independent molecules in the asymmetric unit. Complex 1 exhibits exceptional solubility in aqueous media and leads to the efficient eradication of several bacterial strains upon sustained release of bioactive silver.
已合成并对两种设计的三齿配体，即2,6-(吡啶基)亚氨基二氮杂金刚烷（pydTAm）和2,6-(吡啶基)亚氨基二金刚烷（pydAm）的银(I)配合物进行了结构表征。Ag(pydTAm)（1），一种迄今未知的八面体银(I)配合物的面式异构体，结晶于高度对称的体心立方I4̅3m空间群中。相比之下，类似的Ag(pydAm)（2）配合物中的银中心处于三角双锥几何构型，结晶于三斜P1̅空间群中，不对称单元中有两个晶体学独立分子。配合物1在水性介质中表现出优异的溶解性，并在生物活性银持续释放时导致几种细菌菌株的有效根除。
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