颅内脑膜瘤的放射外科治疗：系统评价和荟萃分析。
Radiosurgery for intracranial meningiomas: A systematic review and meta-analysis.
机构信息
IRCCS Istituto Neurologico Fondazione Carlo Besta, Neurosurgery Department, Radiotherapy Unit, Via G. Celoria 11, 20133 Milan, Italy.
IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy.
出版信息
Crit Rev Oncol Hematol. 2017 May;113:122-134. doi: 10.1016/j.critrevonc.2017.03.005. Epub 2017 Mar 12.
BACKGROUND
Radiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas.
METHODS
Online databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity.
RESULTS
The estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%-98.9% and 53.1%-97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%.
CONCLUSIONS
RS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.
背景
立体定向放射外科（RS），无论是单次还是多次治疗，都已经被应用于颅内脑膜瘤的治疗。这一领域仍有许多方面存在争议。本系统综述的目的是总结目前关于 RS 治疗脑膜瘤的长期疗效和安全性的文献。
方法
检索截至 2015 年 4 月发表的研究。主要结局是疾病控制和无进展生存期（PFS）。次要结局是症状控制和放射诱导的毒性。
结果
5 年时疾病控制率的估计值为 87.0%至 100.0%，10 年时为 67.0%至 100.0%。5 年和 10 年的 PFS 率分别为 78.0%-98.9%和 53.1%-97.2%。总的症状控制率为 92.3%，总的毒性发生率为 8.1%。
结论
RS 可以被认为是一种安全有效的治疗方法。需要努力规范局部控制、症状控制和毒性的定义，以便正确比较不同的治疗方案。
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