National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, United Kingdom; National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Mult Scler Relat Disord. 2017 Apr;13:73-74. doi: 10.1016/j.msard.2017.02.009. Epub 2017 Feb 14.
Paroxysmal tonic spasms [PTS] are common in patients with neuromyelitis optica spectrum disorder (NMOSD).1 2 In patients with demyelinating disease, PTS can significantly reduce the quality of life, limit activities of daily living and the rehabilitative process following an acute relapse 3. As in patients with multiple sclerosis (MS), paroxysmal tonic spasms in NMOSD usually respond well to treatment with carbamazepine.2 However, the optimal treatment in patients where carbamazepine is contraindicated or poorly tolerated is unclear. We describe a patient with NMOSD with severe paroxysmal tonic spasms who did not tolerate carbamazepine but was successfully treated with lacosamide (Vimpat).
阵发性强直性痉挛[PTS]在视神经脊髓炎谱系障碍（NMOSD）患者中很常见。1 2 在脱髓鞘疾病患者中，PTS 会显著降低生活质量，限制日常生活活动，并限制急性复发后的康复过程。3 与多发性硬化症（MS）患者一样，NMOSD 中的阵发性强直性痉挛通常对卡马西平治疗反应良好。2 然而，对于卡马西平禁忌或不耐受的患者，最佳治疗方法尚不清楚。我们描述了一例 NMOSD 患者，其阵发性强直性痉挛严重，不能耐受卡马西平，但用拉考酰胺（利必通）成功治疗。
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