Sato Kei, Akiyama Hirotoshi, Kogure Yuu, Suwa Yusuke, Momiyama Masashi, Ishibe Atsushi, Endo Itaru
Dept. of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2017 Apr;44(4):329-331.
We report a case of rhabdomyolysis related to S-1 plus oxaliplatin(SOX)therapy for liver metastasis of gastric cancer. A 76- year-old man who had received SOX therapy for metastatic gastric cancer was admitted to our hospital for a chief complaint of fatigue and weakness. He diagnosed with rhabdomyolysis related to SOX therapy because of his symptoms and because his laboratory studies showed significant elevation of his serum creatine kinase(CK)level. The symptoms disappeared and the CK level normalized following large-volume transfusions. Rhabdomyolysis following SOX therapy is a very rare, but severe adverse event. This is the first detailed case report of rhabdomyolysis related to SOX therapy.