Asgary Sedigheh, Movahedian Ahmad, Keshvari Mahtab, Taleghani Mahsa, Sahebkar Amirhossein, Sarrafzadegan Nizal
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Chemosphere. 2017 Aug;180:540-544. doi: 10.1016/j.chemosphere.2017.03.069. Epub 2017 Mar 29.
There is a continuing attempt to identify novel factors that can predict the risk of cardiovascular disease beyond the established coronary risk factors. It has been suggested that serum levels of lead, mercury and cadmium are associated with the risk of coronary artery disease (CAD). In the present study, we aimed to evaluate serum concentrations of lead (s-Pb), mercury (s-Hg) and cadmium (s-Cd) in patients with CAD in comparison with those of healthy individuals. The correlation between serum levels of these heavy metals and lipid profile parameters was also investigated.
In this case-control study, we included 65 patients (35 females) aged 50-70 years with angiographically-documented CAD and 65 healthy controls (43 female) matched for sex, age and place of residence. Serum concentrations of heavy metals were determined using graphite furnace atomic absorption (GFAA). Serum lipids were measured using routine enzymatic methods.
It was observed that the mean concentration of s-Pb (12.54 ± 8.41 vs. 5.89 ± 4.44 μg/L, p < 0.05) and s-Cd (0.938 ± 0.72 vs. 0.448 ± 0.30, p < 0.05; CI: 95%) and s-Hg (10.14 ± 5.06 vs. 6.11 ± 5.66, p < 0.05) were significantly higher in CAD patients compared with control subjects. The same result was also obtained after adjustment for cardiovascular risk factors including age, dyslipidemia, diabetes mellitus and hypertension (p < 0.05). The mean concentration of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and TC:HDL-C ratio were significantly higher in CAD patients (p < 0.05). There was no significant association between serum metal concentrations with TC, HDL-C and TC:HDL-C ratio (p > 0.05).
The present results showed that serum levels of heavy metals are associated with the presence of CAD. Long-term exposure to trace levels of Pb, Cd and Hg may play a role in the development of coronary atherosclerotic plaques.
人们一直在努力寻找除已确定的冠状动脉危险因素之外，能够预测心血管疾病风险的新因素。有研究表明，血清铅、汞和镉水平与冠状动脉疾病（CAD）风险相关。在本研究中，我们旨在评估CAD患者与健康个体相比血清铅（s-Pb）、汞（s-Hg）和镉（s-Cd）的浓度。同时还研究了这些重金属血清水平与血脂谱参数之间的相关性。
在这项病例对照研究中，我们纳入了65例年龄在50 - 70岁之间、经血管造影证实患有CAD的患者（35例女性）以及65名在性别、年龄和居住地相匹配的健康对照者（43例女性）。使用石墨炉原子吸收法（GFAA）测定重金属血清浓度。采用常规酶法测量血脂。
观察到CAD患者的s-Pb平均浓度（12.54 ± 8.41 vs. 5.89 ± 4.44 μg/L，p < 0.05）、s-Cd平均浓度（0.938 ± 0.72 vs. 0.448 ± 0.30，p < 0.05；CI：95%）和s-Hg平均浓度（10.14 ± 5.06 vs. 6.11 ± 5.66，p < 0.05）显著高于对照组。在对包括年龄、血脂异常、糖尿病和高血压等心血管危险因素进行校正后，也得到了相同的结果（p < 0.05）。CAD患者的总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）平均浓度以及TC:HDL-C比值显著更高（p < 0.05）。血清金属浓度与TC、HDL-C和TC:HDL-C比值之间无显著关联（p > 0.05）。
目前的结果表明，重金属血清水平与CAD的存在有关。长期接触痕量的铅、镉和汞可能在冠状动脉粥样硬化斑块的形成中起作用。
