Banerjee Debasish Bijoykrishna, Vithana Hasanthi, Sharma Shilpa, Tsang Thomas Tat Ming
Great Ormond Street Hospital for Children NHS Trust, Greater London, London, UK.
Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich, UK.
Pediatr Surg Int. 2017 Jul;33(7):783-786. doi: 10.1007/s00383-017-4084-5. Epub 2017 Apr 22.
Newborns undergoing surgery for necrotizing enterocolitis (NEC) often require a stoma. Currently, there is no consensus regarding the best time for stoma closure (SC). Our aim was to determine the outcomes of early versus late closure.
Retrospective analysis of patients who underwent SC following stoma formation for NEC between Jan 2009 and July 2015 was done. Early (EC) versus late closure (LC) was defined as less than 10 weeks versus at or after 10 weeks of stoma formation.
Of 36 patients, M:F was 23:13. Indications for laparotomy were pneumoperitoneum (30) and gangrene (6). Postoperatively, 9/15 (60.0%) of EC group required ventilator support versus none in LC group (p < 0.05). It took longer to establish full feeds following EC (12 days) versus LC (8 days). Median duration of postoperative hospital stay following EC was 31 days (18-35) versus 7 days (4-54) following LC. Three patients were re-operated for intestinal obstruction (two following EC, one following LC). Three patients developed incisional hernia after EC versus none after LC (p < 0.05). One patient died after EC due to staphylococcus septicaemia.
Early closure before 10 weeks of formation for NEC patients is associated with significant morbidity, increased ventilator requirements and chances of developing incisional hernia.
接受坏死性小肠结肠炎(NEC)手术的新生儿通常需要造口。目前,关于造口关闭(SC)的最佳时机尚无共识。我们的目的是确定早期关闭与晚期关闭的结果。
对2009年1月至2015年7月间因NEC造口形成后接受SC的患者进行回顾性分析。早期关闭(EC)与晚期关闭(LC)的定义为造口形成后少于10周与10周及以后。
36例患者中,男:女为23:13。剖腹手术的指征为气腹(30例)和坏疽(6例)。术后,EC组15例中有9例(60.0%)需要呼吸机支持,而LC组无一例需要(p<0.05)。EC组(12天)建立完全喂养所需时间比LC组(8天)长。EC组术后住院中位时间为31天(18 - 35天),而LC组为7天(4 - 54天)。3例患者因肠梗阻再次手术(2例在EC后,1例在LC后)。EC组3例患者发生切口疝,LC组无(p<0.05)。1例患者在EC后因葡萄球菌败血症死亡。
NEC患者在造口形成10周前进行早期关闭与显著的发病率、增加的呼吸机需求以及发生切口疝的几率相关。