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类风湿关节炎中表观遗传机制紊乱导致的基质金属蛋白酶基因激活

Matrix Metalloproteinase Gene Activation Resulting from Disordred Epigenetic Mechanisms in Rheumatoid Arthritis.

作者信息

Araki Yasuto, Mimura Toshihide

机构信息

Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama 350-0495, Japan.

Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama 350-0495, Japan.

出版信息

Int J Mol Sci. 2017 Apr 25;18(5):905. doi: 10.3390/ijms18050905.

DOI:10.3390/ijms18050905
PMID:28441353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5454818/
Abstract

Matrix metalloproteinases (MMPs) are implicated in the degradation of extracellular matrix (ECM). Rheumatoid arthritis (RA) synovial fibroblasts (SFs) produce matrix-degrading enzymes, including MMPs, which facilitate cartilage destruction in the affected joints in RA. Epigenetic mechanisms contribute to change in the chromatin state, resulting in an alteration of gene transcription. Recently, MMP gene activation has been shown to be caused in RASFs by the dysregulation of epigenetic changes, such as histone modifications, DNA methylation, and microRNA (miRNA) signaling. In this paper, we review the role of MMPs in the pathogenesis of RA as well as the disordered epigenetic mechanisms regulating MMP gene activation in RASFs.

摘要

基质金属蛋白酶（MMPs）与细胞外基质（ECM）的降解有关。类风湿关节炎（RA）滑膜成纤维细胞（SFs）产生包括MMPs在内的基质降解酶，这些酶促进RA患者受累关节中的软骨破坏。表观遗传机制导致染色质状态改变，进而引起基因转录改变。最近研究表明，RA滑膜成纤维细胞（RASFs）中MMP基因的激活是由表观遗传变化失调引起的，如组蛋白修饰、DNA甲基化和微小RNA（miRNA）信号传导。在本文中，我们综述了MMPs在RA发病机制中的作用以及调节RASFs中MMP基因激活的表观遗传机制紊乱情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/53f157244853/ijms-18-00905-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/faf90d81b214/ijms-18-00905-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/e3c2c7cb87ef/ijms-18-00905-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/6482c0d3a72a/ijms-18-00905-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/53f157244853/ijms-18-00905-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/faf90d81b214/ijms-18-00905-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/e3c2c7cb87ef/ijms-18-00905-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/6482c0d3a72a/ijms-18-00905-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d8/5454818/53f157244853/ijms-18-00905-g004.jpg

相似文献

[1]
Matrix Metalloproteinase Gene Activation Resulting from Disordred Epigenetic Mechanisms in Rheumatoid Arthritis.

Int J Mol Sci. 2017-4-25

[2]
Histone Methylation and STAT-3 Differentially Regulate Interleukin-6-Induced Matrix Metalloproteinase Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts.

Arthritis Rheumatol. 2016-5

[3]
The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape.

J Immunol Res. 2016-12-28

[4]
Epigenetic control in rheumatoid arthritis synovial fibroblasts.

Nat Rev Rheumatol. 2009-5

[5]
Epigenetics in the pathogenesis of RA.

Semin Immunopathol. 2017-6

[6]
Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts.

Biochem Biophys Res Commun. 2014-2-7

[7]
New advances of DNA methylation and histone modifications in rheumatoid arthritis, with special emphasis on MeCP2.

Cell Signal. 2012-12-29

[8]
Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts.

Arthritis Rheum. 2010-5

[9]
Epigenetics in rheumatoid arthritis; fibroblast-like synoviocytes as an emerging paradigm in the pathogenesis of the disease.

Immunol Cell Biol. 2020-1-26

[10]
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.

Arthritis Rheum. 2008-4

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Antioxidants (Basel). 2025-7-17

[2]
Photobiomodulation control the expression of MMP, TNF-α and NK-1 receptors, improving allodynia and cartilage resistance in rheumatoid arthritis model.

Lasers Med Sci. 2025-7-1

[3]
Differential Gene Expression in Rheumatoid Arthritis: Implication in the Diagnosis and Individualized Treatment Plan.

J Biotechnol Biomed. 2025

[4]
Preconditioning of bone marrow mesenchymal stem cells with sodium hydrosulfide enhances their therapeutic potential in type II collagen-induced arthritis rat model.

Naunyn Schmiedebergs Arch Pharmacol. 2025-5-14

[5]
Dapagliflozin targets the crosstalk between apoptosis, autophagy, and Hedgehog signaling pathways through AMPK activation in the adjuvant-induced arthritic rat model.

Inflammopharmacology. 2025-5-12

[6]
Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3.

Immune Netw. 2025-2-7

[7]
Trans-anethole enhances mesenchymal stem cell derived exosomes function to inhibit HO-induced rheumatoid arthritis-like inflammation in HIG-82 synovial cells.

Mol Biol Rep. 2025-4-28

[8]
HDAC4 regulates apoptosis in Acan-Cre;HDAC4 mice with osteoarthritis by downregulating ATF4.

FEBS Open Bio. 2025-5

[9]
Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts.

Sci Rep. 2024-5-9

[10]
Unveiling the Nexus: Cellular Metabolomics Unravels the Impact of Estrogen on Nicotinamide Metabolism in Mitigating Rheumatoid Arthritis Pathogenesis.

Metabolites. 2024-4-11

本文引用的文献

[1]
Methylation in the matrix metalloproteinase-2 gene is associated with cerebral ischemic stroke.

J Investig Med. 2017-4

[2]
The Involvement of miR-29b-3p in Arterial Calcification by Targeting Matrix Metalloproteinase-2.

Biomed Res Int. 2017

[3]
The Histone Modification Code in the Pathogenesis of Autoimmune Diseases.

Mediators Inflamm. 2017

[4]
Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression.

J Hematol Oncol. 2017-1-25

[5]
The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape.

J Immunol Res. 2016-12-28

[6]
Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor.

J Exp Med. 2016-9-19

[7]
Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy.

Lab Invest. 2016-10

[8]
Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration.

J Orthop Res. 2017-6

[9]
Histone Methylation and STAT-3 Differentially Regulate Interleukin-6-Induced Matrix Metalloproteinase Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts.

Arthritis Rheumatol. 2016-5

[10]
Dysregulated miR-133a Mediates Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 9 (MMP9) in Human Intervertebral Disc Degeneration.

Spine (Phila Pa 1976). 2016-6

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