Fan Zhe, Zhuang Chengjun
Department of General Surgery, the Third People's Hospital of Dalian, Dalian Medical University, Dalian, China.
Department of ICU, the Second Hospital of Dalian Medical University, Dalian, China
Ann Clin Lab Sci. 2017 Mar;47(2):166-170.
Duodenal ulcer perforation (DUP) is a severe acute abdominal disease. Mean platelet volume (MPV) and platelet distribution width (PDW) are two platelet parameters, participating in many inflammatory processes. This study aims to investigate the relation of MPV/PDW and DUP.
A total of 165 patients were studied retrospectively, including 21 females and 144 males. The study included two groups: 87 normal patients (control group) and 78 duodenal ulcer perforation patients (DUP group). Routine blood parameters were collected for analysis including white blood cell count (WBC), neutrophil ratio (NR), platelet count (PLT), MPV and PDW. Receiver operating curve (ROC) analysis was applied to evaluate the parameters' sensitivity.
No significant differences were observed between the control group and DUP group in age and gender. WBC, NR and PDW were significantly increased in the DUP group (<0.001, respectively); PLT and MPV were significantly decreased in the DUP group (<0.001, respectively) compared to controls. MPV had the high sensitivity.
Our results suggested a potential association between MPV/PDW and disease activity in DUP patients, and high sensitivity of MPV.
十二指肠溃疡穿孔（DUP）是一种严重的急性腹部疾病。平均血小板体积（MPV）和血小板分布宽度（PDW）是两个血小板参数，参与许多炎症过程。本研究旨在探讨MPV/PDW与DUP之间的关系。
回顾性研究了165例患者，其中女性21例，男性144例。该研究包括两组：87例正常患者（对照组）和78例十二指肠溃疡穿孔患者（DUP组）。收集常规血液参数进行分析，包括白细胞计数（WBC）、中性粒细胞比例（NR）、血小板计数（PLT）、MPV和PDW。应用受试者工作特征曲线（ROC）分析来评估这些参数的敏感性。
对照组和DUP组在年龄和性别上无显著差异。与对照组相比，DUP组的WBC、NR和PDW显著升高（分别<0.001）；DUP组的PLT和MPV显著降低（分别<0.001）。MPV具有较高的敏感性。
我们的结果表明MPV/PDW与DUP患者的疾病活动之间可能存在关联，且MPV具有较高的敏感性。
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