Liu Teng, Tian Lixia, Lai Junshan, Min Deng, Qu Mengnan, Tang Shouchu
School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Org Biomol Chem. 2017 May 16;15(19):4068-4071. doi: 10.1039/c7ob00795g.
An alcohol-mediated dithioacetalization process that gains direct access to the corresponding Markovnikov-selective 1,3-dithianes using unactivated alkynes and nonthiolic/odorless 2-chloro-1,3-dithiane in a highly efficient manner has been developed. This methodology has the advantage of having mild reaction conditions, and the dithioacetalization process gives good to excellent yields with high Markovnikov-selectivity.
已开发出一种醇介导的二硫缩醛化过程，该过程能够以高效的方式，使用未活化的炔烃和非硫醇/无味的2-氯-1,3-二硫戊环直接得到相应的马氏选择性1,3-二硫戊环。该方法具有反应条件温和的优点，并且二硫缩醛化过程能以高马氏选择性给出良好至优异的产率。
