Kamate Wasim, Baad Rajendra, Vibhute Nupura, Belgaumi Uzma, Kadashetti Vidya, Gugwad Sushma
Department of Oral Pathology and Microbiology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University (KIMSDU), Karad, India.
Int J Stem Cells. 2017 May 30;10(1):21-27. doi: 10.15283/ijsc16065.
Tumor-initiating cells are a diminutive subpopulation of stem cells that have ability of long term self-renewal and generation of varied traits of tumor cell population. Understanding the concept of tumor-initiating cells may have a great implicative intimation for our comprehension of cancer pathobiology and for the delineation of new therapies directed towards these stem cells. The present review is an endeavor to conceptualize the role of tumor-initiating cells in the Squamous Cell Cancers (SCC) of head and neck, their role in tumorigenesis and the possible supplementary approach in the latest treatment modalities.
肿瘤起始细胞是干细胞中的一个微小亚群，具有长期自我更新能力，并能产生具有不同特征的肿瘤细胞群体。理解肿瘤起始细胞的概念，对于我们理解癌症病理生物学以及描绘针对这些干细胞的新疗法可能具有重大的启示意义。本综述旨在阐述肿瘤起始细胞在头颈部鳞状细胞癌中的作用、它们在肿瘤发生中的作用以及最新治疗模式中可能的补充方法。
