Kim Sun Y, Webb Ashley E
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Nutr Healthy Aging. 2017 Mar 31;4(2):113-126. doi: 10.3233/NHA-160009.
The FOXO family of transcription factors plays a conserved role in longevity and tissue homeostasis across species. In the mammalian nervous system, emerging evidence has implicated FOXOs in cognitive performance, stem cell maintenance, regeneration, and protection against stress. Much of what we know about neuronal functions of FOXO emerged from recent studies in Similar to mammalian FOXO, the worm FOXO ortholog, called DAF-16, regulates learning and memory, regeneration, and stress resistance in neurons. Here, we discuss the current state of our knowledge of FOXO's functions in neurons in mammals and invertebrates, and highlight areas where our understanding is limited. Defining the function of FOXO factors in the healthy, aged, and diseased brain may have important implications for improving healthspan and treating neurodegenerative disease.
转录因子FOXO家族在物种间的寿命和组织稳态中发挥着保守作用。在哺乳动物神经系统中，新出现的证据表明FOXO与认知能力、干细胞维持、再生以及应激保护有关。我们对FOXO神经元功能的许多了解都来自于近期对 的研究。与哺乳动物的FOXO相似，线虫的FOXO直系同源基因DAF-16调节神经元的学习和记忆、再生以及应激抗性。在这里，我们讨论了目前我们对FOXO在哺乳动物和无脊椎动物神经元中功能的了解情况，并强调了我们理解有限的领域。明确FOXO因子在健康、衰老和患病大脑中的功能可能对改善健康寿命和治疗神经退行性疾病具有重要意义。
