Shridharani Sachin M
LUXURGERY, New York, New York.
Dermatol Surg. 2017 Jul;43(7):950-958. doi: 10.1097/DSS.0000000000001133.
Deoxycholic acid (DCA) is approved for improvement in the appearance of moderate to severe convexity or fullness associated with submental fat.
To assess early treatment experience with DCA injection in a clinical practice setting.
In this single-center, prospective, single-arm, observational study, 100 consecutive patients seeking to decrease submental fullness received subcutaneous DCA (2 mg/cm) injections in the submental area (maximum of 6 sessions at ≥1 month intervals). Treatment response was assessed 1 and 5 to 7 weeks posttreatment using the clinician-reported submental fat rating scale (CR-SMFRS) and retrospective independent photograph review by 2 physicians.
Overall, 100 patients had 152 treatment sessions (58, 33, 8, and 1 patients had 1, 2, 3, and 4 sessions, respectively). CR-SMFRS score improved by ≥1 point from baseline in 88 (88%) patients; of these, 46, 33, 8, and 1 patients had 1, 2, 3, and 4 sessions, respectively. Local edema, numbness, and tenderness were reported for a mean (SD) of 7.7 (5.3), 28.5 (11.4), and 3.5 (3.5) days, respectively. Two patients experienced marginal mandibular nerve paresis.
Deoxycholic acid injection, a minimally invasive procedure for neck contouring, was effective and generally well tolerated in the private practice setting.
脱氧胆酸（DCA）已被批准用于改善与颏下脂肪相关的中度至重度凸度或丰满外观。
评估在临床实践中进行DCA注射的早期治疗经验。
在这项单中心、前瞻性、单臂观察性研究中，100例连续寻求减少颏下丰满度的患者在颏下区域接受皮下DCA（2mg/cm）注射（最多6次，间隔≥1个月）。在治疗后1周以及5至7周，使用临床医生报告的颏下脂肪评级量表（CR-SMFRS）和两名医生进行的回顾性独立照片评估来评估治疗反应。
总体而言，100例患者共进行了152次治疗（58例、33例、8例和1例患者分别接受了1次、2次、3次和4次治疗）。88例（88%）患者的CR-SMFRS评分较基线提高了≥1分；其中，46例、33例、8例和1例患者分别接受了1次、2次、3次和4次治疗。局部水肿、麻木和压痛的平均（标准差）持续时间分别为7.7（5.3）天、28.5（11.4）天和3.5（3.5）天。两名患者出现下颌缘支神经麻痹。
脱氧胆酸注射作为一种用于颈部塑形的微创手术，在私人诊所环境中有效且耐受性良好。
