Rajanandh M G, Suresh S, Manobala K, Nandhakumar R, Jaswanthi G, Neha S
1 Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Chennai, India.
2 Department of Medical Oncology, Sri Ramachandra Medical College and Hospital, Sri Ramachandra University, Chennai, India.
J Oncol Pharm Pract. 2018 Jul;24(5):354-358. doi: 10.1177/1078155217707334. Epub 2017 Apr 28.
Objective Despite the fact that cancer and heart diseases are interconnected, there is lack of information about the prevalence of cardiovascular risk in cancer patients in the South Indian population. With this background, the present study sought to predict the cardiovascular disease in cancer patients. Methods A prospective, cross-sectional study was conducted in the Department of Medical Oncology, Sri Ramachandra University and Hospital, India. Patients' demographic details, medical information, height, weight, body mass index, blood pressure, total cholesterol and HDL-cholesterol were measured. Two risk prediction tools, namely World Health Organization/International Society of hypertension (WHO/ISH) risk prediction charts and Framingham score were used to assess the prevalence of cardiovascular risk over 10 years. Results A total of 70 patients were included for the study. Breast and stomach cancer were found to be most among the study patients. Cardiovascular disease was assessed using WHO/ISH and Framingham risk assessment tool. With respect to WHO/ISH risk, there is a significant difference in gender, type of cancer, smoking status and age between the risk groups. Males have a high risk compared to females, and smokers have a high risk compared to non-smokers. With respect to Framingham score, there is a significant difference in gender, smoking status and systolic blood pressure between the risk groups. Males have a high risk compared to females, and smokers have a high risk compared to non-smokers. A moderate degree of agreement exists between the two risk prediction tools. Conclusion The findings of the study revealed that there is a low risk of cardiovascular disease in cancer patients.
目的 尽管癌症和心脏病相互关联，但关于印度南部人群癌症患者心血管风险的患病率信息匮乏。在此背景下，本研究旨在预测癌症患者的心血管疾病。方法 在印度斯里兰卡拉马钱德拉大学医院医学肿瘤学系进行了一项前瞻性横断面研究。测量了患者的人口统计学细节、医疗信息、身高、体重、体重指数、血压、总胆固醇和高密度脂蛋白胆固醇。使用两种风险预测工具，即世界卫生组织/国际高血压学会（WHO/ISH）风险预测图表和弗明汉评分，来评估10年内心血管风险的患病率。结果 共有70名患者纳入研究。研究患者中乳腺癌和胃癌最为常见。使用WHO/ISH和弗明汉风险评估工具评估心血管疾病。关于WHO/ISH风险，风险组之间在性别、癌症类型、吸烟状况和年龄方面存在显著差异。男性比女性风险高，吸烟者比非吸烟者风险高。关于弗明汉评分，风险组之间在性别、吸烟状况和收缩压方面存在显著差异。男性比女性风险高，吸烟者比非吸烟者风险高。两种风险预测工具之间存在中度一致性。结论 研究结果显示癌症患者患心血管疾病的风险较低。
