猫在低频垂直旋转过程中垂直前庭眼反射的适应性
Adaptation of the vertical vestibulo-ocular reflex in cats during low-frequency vertical rotation.
作者信息
Fushiki Hiroaki, Maruyama Motoyoshi, Shojaku Hideo
机构信息
Otolaryngology, Mejiro University Ear Institute Clinic, Saitama, Japan; Department of Otolaryngology, University of Toyama, Toyama, Japan.
Otolaryngology, Hokuriku Central Hospital, Toyama, Japan; Department of Otolaryngology, University of Toyama, Toyama, Japan.
出版信息
Auris Nasus Larynx. 2018 Apr;45(2):242-247. doi: 10.1016/j.anl.2017.04.001. Epub 2017 Apr 28.
OBJECTIVE
We examined plastic changes in the vestibulo-ocular reflex (VOR) during low-frequency vertical head rotation, a condition under which otolith inputs from the vestibular system are essential for VOR generation.
METHODS
For adaptive conditioning of the vertical VOR, 0.02Hz sinusoidal pitch rotation for one hour about the earth's horizontal axis was synchronized with out-of-phase vertical visual stimulation from a random dot pattern.
RESULTS
A vertical VOR was well evoked when the upright animal rotated around the earth-horizontal axis (EHA) at low frequency due to the changing gravity stimulus and dynamic stimulation of the otoliths. After adaptive conditioning, the amplitude of the vertical VOR increased by an average of 32.1%.
CONCLUSION
Our observations showing plasticity in the otolithic contribution to the VOR may provide a new strategy for visual-vestibular mismatch training in patients with otolithic disorders. This low-frequency vertical head rotation protocol also provides a model for investigating the mechanisms underlying the adaptation of VORs mediated by otolith activation.
目的
我们研究了低频垂直头部旋转过程中前庭眼反射（VOR）的可塑性变化，在此条件下，来自前庭系统的耳石输入对于VOR的产生至关重要。
方法
为了对垂直VOR进行适应性调节，将以0.02Hz围绕地球水平轴进行一小时的正弦俯仰旋转与来自随机点图案的异相垂直视觉刺激同步。
结果
当直立动物由于重力刺激的变化和耳石的动态刺激而在低频下围绕地球水平轴（EHA）旋转时，垂直VOR被很好地诱发。适应性调节后，垂直VOR的幅度平均增加了32.1%。
结论
我们的观察结果表明耳石对VOR的贡献具有可塑性，这可能为耳石疾病患者的视前庭不匹配训练提供一种新策略。这种低频垂直头部旋转方案也为研究耳石激活介导的VOR适应机制提供了一个模型。
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