低强度脉冲超声诱导大鼠脊柱融合与降钙素基因相关肽表达增强相关

Low-Intensity Pulsed Ultrasound-Induced Spinal Fusion is Coupled with Enhanced Calcitonin Gene-Related Peptide Expression in Rat Model.

作者信息

Zhou Xiao-Yi, Xu Xi-Ming, Wu Sui-Yi, Wang Fei, Zhang Zi-Cheng, Yang Yi-Lin, Li Ming, Wei Xian-Zhao

机构信息

Department of Orthopedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

Department of Spinal Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

出版信息

Ultrasound Med Biol. 2017 Jul;43(7):1486-1493. doi: 10.1016/j.ultrasmedbio.2017.03.012. Epub 2017 Apr 28.

DOI:10.1016/j.ultrasmedbio.2017.03.012

PMID:28457632

Abstract

Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate fracture healing. In this study, we analyzed the role of calcitonin gene-related peptide (CGRP) in a rat spinal fusion model treated with LIPUS. The results revealed that LIPUS significantly increases bone formation, and the process was coupled with elevated CGRP innervation. CGRP was located in fibrous tissue, closely surrounding the allograft and newly formed cartilage. The density of CGRP peaked at week 3 after surgery in both the control (non-LIPUS-treated) and LIPUS-treated groups. These results suggest that LIPUS might accelerate spinal fusion by promoting sensory nerve fiber innervation.

摘要

低强度脉冲超声（LIPUS）已被发现可加速骨折愈合。在本研究中，我们分析了降钙素基因相关肽（CGRP）在接受LIPUS治疗的大鼠脊柱融合模型中的作用。结果显示，LIPUS显著增加骨形成，且该过程伴随着CGRP神经支配的增加。CGRP位于纤维组织中，紧密围绕同种异体移植物和新形成的软骨。在对照组（未接受LIPUS治疗）和接受LIPUS治疗的组中，CGRP密度在术后第3周达到峰值。这些结果表明，LIPUS可能通过促进感觉神经纤维的神经支配来加速脊柱融合。