Lee Jung Eun, Namkoong Kee, Jung Young-Chul
Eunpyeong Hospital, Baekryunsanro 90, Eunpyeongku, Seoul, South Korea; Department of Psychiatry, Yonsei University College of Medicine, Yonseiro 50-1, Seodaemoonku, Seoul, South Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Yonseiro 50-1, Seodaemoonku, Seoul, South Korea.
Department of Psychiatry, Yonsei University College of Medicine, Yonseiro 50-1, Seodaemoonku, Seoul, South Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Yonseiro 50-1, Seodaemoonku, Seoul, South Korea.
Neurosci Lett. 2017 Jun 9;651:95-101. doi: 10.1016/j.neulet.2017.04.054. Epub 2017 Apr 27.
Binge-eating disorder (BED)characterized by recurrent episodes of binge-eating without inappropriate compensatory behaviors is classified as an official diagnosis in DSM-5. However, the neural bases that differentiate BED from other eating disorders such as bulimia nervosa (BN), are still under debate. Thirty-nine participants (HC, n=14; BN, n=13; BED, n=12) underwent functional MRI while performing a Stroop-Match-to-Sample task. This pilot study investigated how food images interfered with the behavioral performances and blood-oxygenation-level-dependent neuronal activity. Compared to healthy controls, participants with BN showed lower accuracy indicating impaired cognitive control over interference. Compared to healthy controls, participants with BED demonstrated stronger activations in the ventral striatum in response to food images. By contrast, participants with BN exhibited stronger activations in the premotor cortex and dorsal striatum. These aberrant ventral and dorsal frontostriatal activations in response to food images are associated with increased reward sensitivity and habitual binge-eating/purging behaviors in BED and BN.
暴饮暴食症（BED）的特征是反复出现暴饮暴食发作且无不当代偿行为，在《精神疾病诊断与统计手册》第五版（DSM - 5）中被列为正式诊断疾病。然而，将暴饮暴食症与神经性贪食症（BN）等其他饮食失调症区分开来的神经基础仍存在争议。39名参与者（健康对照组，n = 14；神经性贪食症组，n = 13；暴饮暴食症组，n = 12）在执行一项色词干扰匹配样本任务时接受了功能磁共振成像检查。这项初步研究调查了食物图像如何干扰行为表现以及血氧水平依赖的神经元活动。与健康对照组相比，神经性贪食症患者的准确率较低，表明对干扰的认知控制受损。与健康对照组相比，暴饮暴食症患者在看到食物图像时腹侧纹状体的激活更强。相比之下，神经性贪食症患者在前运动皮层和背侧纹状体的激活更强。这些对食物图像的腹侧和背侧额纹状体异常激活与暴饮暴食症和神经性贪食症中增加的奖赏敏感性以及习惯性暴饮暴食/清除行为有关。
