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Linn.叶提取物对成年小鼠急性束缚应激诱导的抑郁样行为症状的神经保护作用。

Neuroprotective effect of Linn. leaves extract against acute restraint stress-induced depressive-like behavioral symptoms in adult mice.

作者信息

Vazhayil Babitha K, Rajagopal Shanmuga Sundaram, Thangavelu Thiyagarajan, Swaminathan Gomathi, Rajagounder Elavarasi

机构信息

Department of Pharmaceutical Chemistry, J. K. K. Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu, India.

Department of Pharmacology, J. K. K. Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu, India.

出版信息

Indian J Pharmacol. 2017 Jan-Feb;49(1):34-41. doi: 10.4103/0253-7613.201028.

DOI:10.4103/0253-7613.201028
PMID:28458420
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5351235/
Abstract

OBJECTIVE

The objective of this study was to study the effect of ethanol extract of (EECS) Linn. on acute restraint stress (ARS)-induced depressive-like behavior and biochemical alterations in mice.

MATERIALS AND METHODS

Ethyl acetate and n-butanol fractions of EECS were analytically characterized for the flavonoid components, apigenin (API) and luteolin (LUT) by reverse-phase high-performance liquid chromatography. Behavioral tests, namely, forced-swim test and tail-suspension test were performed for assessing antidepressant-like effect and anxiolytic activity in mice. Oxidative stress parameters and biochemical alterations in mice brain tissue were also performed.

STATISTICAL ANALYSIS

Expression of data was done as mean ± standard error of mean. The normally distributed data were subjected to two-way ANOVA followed by Dunnett's test. < 0.05 was considered statistically significant.

RESULTS

The study showed that flavonoids, API and LUT were present in ethyl acetate and n-butanol fractions of EECS, which significantly reversed ARS-induced depressive-like behavior without affecting locomotion. EECS also attenuated oxidative damage caused by ARS. The level of norepinephrine and 5-hydroxytryptamine was also significantly restored by pretreatment with EECS for 7 days.

CONCLUSION

EECS significantly alleviated ARS-induced depressive-like behavior without affecting locomotion.

摘要

目的

本研究旨在探讨[植物名称]乙醇提取物（EECS）对急性束缚应激（ARS）诱导的小鼠抑郁样行为和生化改变的影响。

材料与方法

采用反相高效液相色谱法对EECS的乙酸乙酯和正丁醇馏分中的黄酮类成分芹菜素（API）和木犀草素（LUT）进行分析表征。进行行为学测试，即强迫游泳试验和悬尾试验，以评估小鼠的抗抑郁样作用和抗焦虑活性。还检测了小鼠脑组织中的氧化应激参数和生化改变。

统计学分析

数据以平均值±平均标准误差表示。对正态分布的数据进行双向方差分析，然后进行Dunnett检验。P<0.05被认为具有统计学意义。

结果

研究表明，EECS的乙酸乙酯和正丁醇馏分中存在黄酮类化合物API和LUT，它们能显著逆转ARS诱导的抑郁样行为，且不影响运动能力。EECS还减轻了ARS引起的氧化损伤。用EECS预处理7天也能显著恢复去甲肾上腺素和5-羟色胺的水平。

结论

EECS能显著减轻ARS诱导的抑郁样行为，且不影响运动能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/fbf00dba7391/IJPharm-49-34-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/8d86a76067ff/IJPharm-49-34-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/b7ec88e9eb62/IJPharm-49-34-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/8a6e6543e328/IJPharm-49-34-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/04d3a4d76e2b/IJPharm-49-34-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/1a0b0909544f/IJPharm-49-34-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/fbf00dba7391/IJPharm-49-34-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/8d86a76067ff/IJPharm-49-34-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/b7ec88e9eb62/IJPharm-49-34-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/8a6e6543e328/IJPharm-49-34-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/04d3a4d76e2b/IJPharm-49-34-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/1a0b0909544f/IJPharm-49-34-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba9/5351235/fbf00dba7391/IJPharm-49-34-g006.jpg

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