钠钾ATP酶：不同人体组织中编码α亚基的基因的组织特异性表达

Na+,K+-ATPase: tissue-specific expression of genes coding for alpha-subunit in diverse human tissues.

作者信息

Sverdlov E D, Akopyanz N S, Petrukhin K E, Broude N E, Monastyrskaya G S, Modyanov N N

机构信息

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.

出版信息

FEBS Lett. 1988 Oct 24;239(1):65-8. doi: 10.1016/0014-5793(88)80546-5.

DOI:10.1016/0014-5793(88)80546-5

PMID:2846349

Abstract

The expression of genes coding for alpha and alpha III isoforms of Na+,K+-ATPase alpha-subunit has been studied in human kidney, brain, thyroid and liver cells. The expression was shown to be subjected to a tissue-specific control and also depended on the developmental stage. The tissue-specific expression of genes coding for different isoforms of the catalytic subunit of Na+,K+-ATPase perhaps may be attributed to various functions of proteins belonging to this family.

摘要

已对编码 Na +，K + -ATP 酶α亚基的α和αIII 同工型的基因在人肾、脑、甲状腺和肝细胞中的表达进行了研究。结果表明，这种表达受组织特异性控制，并且还取决于发育阶段。编码 Na +，K + -ATP 酶催化亚基不同同工型的基因的组织特异性表达，可能归因于该家族蛋白质的各种功能。