绞股蓝皂苷酸水解产物中的细胞毒性三萜类化合物。
Cytotoxic triterpenes from the acid hydrolyzate of Gynostemma pentaphyllum saponins.
作者信息
Shi Lin, Tan De-Hong, Yan Ting-Cai, Jiang Dong-Hua, Hou Ming-Xiao
机构信息
a College of Food Science, Shenyang Agricultural University , Shenyang 110866 , China.
b Laboratory of Rescue Center of Severe Wound and Trauma PLA, Department of Emergency Medicine , General Hospital of Shenyang Military Command , Shenyang 110016 , China.
出版信息
J Asian Nat Prod Res. 2018 Feb;20(2):182-187. doi: 10.1080/10286020.2017.1322070. Epub 2017 May 2.
One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins from Gynostemma pentaphyllum (Thunb.) Makino, together with two known compounds, (20S,24S)-3β,20,21β,23β,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3β-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (3). Its structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, HR-TOF-MS, and NMR. The cytotoxic activities were evaluated against HepG2 and A549 human cancer cell lines.
从绞股蓝总皂苷的酸水解产物中分离得到一个新的达玛烷型三萜——绞股蓝皂苷元A（1），以及两个已知化合物，即(20S,24S)-3β,20,21β,23β,25-五羟基-21,24-环达玛烷（2）和(23S)-3β-羟基达玛-20,24-二烯-21-酸21,23-内酯（3）。其结构解析主要基于红外光谱（IR）、高分辨飞行时间质谱（HR-TOF-MS）和核磁共振（NMR）等光谱数据的分析。对其针对肝癌细胞系HepG2和肺癌细胞系A549的细胞毒性活性进行了评估。
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