Chiofalo Benito, Laganà Antonio Simone, Vaiarelli Alberto, La Rosa Valentina Lucia, Rossetti Diego, Palmara Vittorio, Valenti Gaetano, Rapisarda Agnese Maria Chiara, Granese Roberta, Sapia Fabrizio, Triolo Onofrio, Vitale Salvatore Giovanni
Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Unit of Psychodiagnostics and Clinical Psychology, University of Catania, Catania, Italy.
Biomed Res Int. 2017;2017:6073167. doi: 10.1155/2017/6073167. Epub 2017 Mar 29.
Placenta is the crucial organ for embryo and fetus development and plays a critical role in the development of fetal growth restriction (FGR). There are increasing evidences on the role of microRNAs (miRNAs) in a variety of pregnancy-related complications such as preeclampsia and FGR. More than 1880 miRNAs have been reported in humans and most of them are expressed in placenta. In this paper, we aimed to review the current evidence about the topic. According to retrieved data, controversial results about placental expression of miRNAs could be due (at least in part) to the different experimental methods used by different groups. Despite the fact that several authors have demonstrated a relatively easy and feasible detection of some miRNAs in maternal whole peripheral blood, costs of these tests should be reduced in order to increase cohorts and have stronger evidence. In this regard, we take the opportunity to solicit future studies on large cohort and adequate statistical power, in order to identify a panel of biomarkers on maternal peripheral blood for early diagnosis of FGR.
胎盘是胚胎和胎儿发育的关键器官，在胎儿生长受限（FGR）的发生发展中起关键作用。越来越多的证据表明，微小RNA（miRNA）在多种妊娠相关并发症如子痫前期和FGR中发挥作用。人类已报道了1880多种miRNA，其中大多数在胎盘中表达。在本文中，我们旨在综述关于该主题的现有证据。根据检索到的数据，关于miRNA在胎盘表达的有争议结果（至少部分）可能归因于不同研究小组使用的不同实验方法。尽管有几位作者已证明在孕妇外周血中检测某些miRNA相对容易且可行，但为了增加样本量并获得更有力的证据，这些检测的成本应降低。在这方面，我们借此机会呼吁开展关于大样本队列和足够统计效力的未来研究，以便确定一组孕妇外周血生物标志物用于FGR的早期诊断。
