In exonization events, may provide donor and/or acceptor sites for splicing after inserting into genes and be incorporated into new transcripts with new exon(s). In this study, the protein variants of exonization yielding additional functional profile(s) were studied. Unlike exonization, which creates new profiles mostly by incorporating flanking intron sequences with the message, exonization additionally creates new profiles through the presence or absence of messages. The number of unique functional profiles harboring messages is 1.3-fold more than that of functional profiles without messages. The highly similar 11 protein isoforms at a single insertion site also contribute to proteome complexity enrichment by exclusively creating new profiles. Particularly, exonization produces 459 unique profiles, of which 129 cannot be built by . We thus conclude that and are independent but synergistic in their capacity to enrich proteome complexity through exonization.