Design, Synthesis and Fungicidal Activity of 2-Substituted Phenyl-2-oxo-, 2-Hydroxy- and 2-Acyloxyethylsulfonamides.

Sulfonyl-containing compounds, which exhibit a broad spectrum of biological activities, comprise a substantial proportion of and play a vital role, not only in medicines but also in agrochemicals. As a result increasing attention has been paid to the research and development of sulfonyl derivatives. A series of thirty-eight 2-substituted phenyl-2-oxo- , 2-hydroxy- and 2-acyloxyethylsulfonamides were obtained and their structures confirmed by IR, ¹H-NMR, and elemental analysis. The in vitro and in vivo bioactivities against two strains, and , which differ in their sensitivity to procymidone, were evaluated. The in vitro activity results showed that the EC values of compounds and were 0.10, 0.01 mg L against the sensitive strain and 3.32, 7.72 mg L against the resistant strain , respectively. For in vivo activity against , compound and showed better control effect than the commercial fungicides procymidone and pyrimethanil. The further in vitro bioassay showed that compounds , and had broad fungicidal spectra against different phytopathogenic fungi. Most of the title compounds showed high fungicidal activities, which could be used as lead compounds for further developing novel fungicidal compounds against .