造血干细胞移植后播散性弓形虫病表现出异常的磁共振图像。
Disseminated toxoplasmosis after hematopoietic stem cell transplantation showing unusual magnetic resonance images.
作者信息
Tateno Takahiro, Onozawa Masahiro, Hashiguchi Junichi, Ishio Takashi, Yuzawa Sayaka, Matsuoka Satomi, Kosugi-Kanaya Mizuha, Okada Kohei, Shiratori Souichi, Goto Hideki, Kimura Taichi, Sugita Junichi, Nakagawa Masao, Hashimoto Daigo, Kahata Kaoru, Fujimoto Katsuya, Endo Tomoyuki, Kondo Takeshi, Tanaka Shinya, Hashino Satoshi, Teshima Takanori
机构信息
Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12720. Epub 2017 Jun 20.
We herein report a patient who had disseminated toxoplasmosis after hematopoietic stem cell transplantation showing atypical clinical presentation and neuroimaging. Parkinsonism symptoms such as muscle rigidity, bradykinesia, tremor, and postural instability were initial manifestations. Magnetic resonance imaging showed diffuse symmetrical lesions of bilateral basal ganglia lacking ringed enhancement. Post-mortem analysis revealed multiple tachyzoites of Toxoplasma gondii in the basal ganglia, mid brain, cerebellum, and cardiac muscle.
我们在此报告一名造血干细胞移植后发生播散性弓形虫病的患者，其临床表现和神经影像学表现均不典型。最初的表现为帕金森氏症症状，如肌肉僵硬、运动迟缓、震颤和姿势不稳。磁共振成像显示双侧基底神经节弥漫性对称性病变，无环形强化。尸检分析显示，在基底神经节、中脑、小脑和心肌中发现多个刚地弓形虫速殖子。
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