Whittaker J A, Withey J, Powell D E, Parry T E, Khurshid M
Br J Haematol. 1979 Feb;41(2):177-84. doi: 10.1111/j.1365-2141.1979.tb05846.x.
A panel of five haematologists has examined, without consultation or prior knowledge of the diagnosis, blood films and bone marrow smears from 456 patients with a diagnosis of leukaemia. A diagnostic classification which recognized various subtypes of acute myelogenous leukaemia was used but no attempt was made to subdivide acute lymphoblastic leukaemia. Complete agreement with the initial diagnosis was low (56.4%) and was particularly poor (45.7%) when the patient had one of the forms of acute leukaemia. However, disagreements which would have involved the patient in a change of treatment were unusual (2.0%). We conclude that a high degree of diagnostic agreement for patients with leukaemia is unlikely from morphological classifications alone.
由五名血液学家组成的小组在未进行会诊且事先不知道诊断结果的情况下，检查了456例诊断为白血病患者的血涂片和骨髓涂片。采用了一种能识别急性髓性白血病各种亚型的诊断分类方法，但未尝试对急性淋巴细胞白血病进行细分。与初始诊断的完全一致率较低（56.4%），当患者患有急性白血病的某种类型时，一致率尤其低（45.7%）。然而，可能会使患者治疗方案改变的分歧并不常见（2.0%）。我们得出结论，仅靠形态学分类，白血病患者不太可能获得高度的诊断一致性。
