[膀胱病变切除术后甲氨蝶呤相关弥漫性大B细胞淋巴瘤的自发消退]
[Spontaneous regression of methotrexate-related diffuse large B-cell lymphoma following bladder lesion resection].
作者信息
Yamada Michiko, Kuroda Hiroyuki, Sato Ken, Miura Shogo, Ameda Saki, Sakano Hiroya, Shibata Takanori, Uemura Naoki, Abe Tomoyuki, Fujii Shigeyuki, Maeda Masahiro, Fujita Miri, Kato Junji
机构信息
Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital.
Dept. of Pathology and Clinical Laboratory, Steel Memorial Muroran Hospital.
出版信息
Rinsho Ketsueki. 2017;58(4):287-291. doi: 10.11406/rinketsu.58.287.
A 71-year-old woman who had been treated with methotrexate (MTX) and prednisolone for rheumatoid arthritis since 2010 presented with hematuria. Cystitis was diagnosed. Chest and abdominal CT images revealed a bladder tumor, with lung and bilateral adrenal metastases. Transurethral resection of the bladder tumor (TUR-BT) confirmed these findings in September 2014. Histological findings of the bladder included large atypical lymphoid cells indicating diffuse large B-cell lymphoma. After TUR-BT, CT imaging showed that the tumor had shrunk. Still, MTX was continued. She was diagnosed with MTX-related lymphoproliferative disorders in November 2014 and MTX was discontinued. Fluorodeoxyglucose-positron emission tomography on March 2015 showed a complete response.
一名71岁女性自2010年起因类风湿关节炎接受甲氨蝶呤（MTX）和泼尼松龙治疗，出现血尿。诊断为膀胱炎。胸部和腹部CT图像显示膀胱肿瘤，伴有肺和双侧肾上腺转移。2014年9月经尿道膀胱肿瘤切除术（TUR-BT）证实了这些发现。膀胱组织学检查发现包括提示弥漫性大B细胞淋巴瘤的大型非典型淋巴细胞。TUR-BT后，CT成像显示肿瘤缩小。尽管如此，MTX仍继续使用。2014年11月她被诊断为MTX相关淋巴增殖性疾病，MTX停用。2015年3月的氟脱氧葡萄糖正电子发射断层扫描显示完全缓解。
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