Kaski Diego, Bronstein Adolfo M
Division of Brain Sciences, Department of Neuro-Otology, Imperial College London, London, UK.
Department of Neuro-Otology, University College London, National Hospital for Neurology and Neurosurgery, London, UK.
Front Neurol. 2017 Apr 24;8:134. doi: 10.3389/fneur.2017.00134. eCollection 2017.
The identification of ocular tremor in a small cohort of patients with Parkinson's disease (PD) had lay somewhat dormant until the recent report of a pervasive ocular tremor as a universal finding in a large PD cohort that was, however, generally absent from a cohort of age-matched healthy subjects. The reported tremor had frequency characteristics similar to those of PD limb tremor, but the amplitude and frequency of the tremor did not correlate with clinical tremor ratings. Much controversy ensued as to the origin of such a tremor, and specifically as to whether a pervasive ocular tremor was a fundamental feature of PD, or rather a compensatory eye oscillation secondary to a transmitted head tremor, and thus a measure of a normal vestibulo-ocular reflex. In this mini review, we summarize some of the evidence for and against the case for a pervasive ocular tremor in PD and suggest future experiments that may help resolve these conflicting opinions.
在一小群帕金森病（PD）患者中发现的眼球震颤，在近期一份关于广泛存在的眼球震颤的报告之前一直处于相对沉寂状态。这份报告指出，在一大群帕金森病患者中，广泛存在的眼球震颤是一个普遍现象，但在年龄匹配的健康受试者群体中通常不存在。报告中所描述的震颤频率特征与帕金森病肢体震颤相似，但震颤的幅度和频率与临床震颤评级并无关联。关于这种震颤的起源引发了诸多争议，特别是关于广泛存在的眼球震颤是帕金森病的一个基本特征，还是继发于传递性头部震颤的一种代偿性眼球摆动，从而是正常前庭眼反射的一种表现。在这篇小型综述中，我们总结了支持和反对帕金森病中广泛存在眼球震颤这一观点的一些证据，并提出了可能有助于解决这些相互矛盾观点的未来实验。
