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腹腔镜结直肠癌手术用于肿瘤性和非肿瘤性切除的成本效益的批判性评估。

A critical appraisal of the cost effectiveness of laparoscopic colorectal surgery for oncological and non-oncological resections.

作者信息

Sajid Muhammad Shafique, Rathore Munir Ahmad, Baig Mirza Khurrum, Sains Parv

机构信息

Department of Gastrointestinal Surgery, Brighton and Sussex University Hospitals NHS Foundation Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, UK.

Department of General, Endoscopic and Laparoscopic Colorectal Surgery, United Lincolnshire Hospitals NHS Trust, Pilgrims Hospital, Sibsey Road, Boston, Lincolnshire, PE21 9QS, UK.

出版信息

Updates Surg. 2017 Sep;69(3):339-344. doi: 10.1007/s13304-017-0458-4. Epub 2017 May 10.

Abstract

The aim of this study was to critically appraise the cost effectiveness of the laparoscopic colorectal (LCRS) surgery using published randomised, control trials (RCTs). Published RCTs comparing the cost effectiveness of LCRS with conventional open surgery were selected from the search of standard electronic databases and the extracted data were analysed using the statistical software RevMan 5.3. Seven RCTs on 2197 patients reported the cost effectiveness of the LCRS. There was significant heterogeneity (τ  = 161,772.25, χ  = 166.69, df = 6, p = 0.00001, I  = 96%) among included randomised, controlled trials. In the random effects model analysis (MD 320.37, 95% CI -38.21, 678.95, z = 1.75, p < 0.08), the LCRS was costing £320.37 more than open colorectal resection but it failed to reach the statistical significance indicating that LCRS is as much cost effective as the open approach. LCRS is a cost effective intervention and should be offered routinely to all patients requiring colorectal resections provided the resources and expertise are available.

摘要

本研究的目的是通过已发表的随机对照试验(RCT)对腹腔镜结直肠手术(LCRS)的成本效益进行批判性评估。从标准电子数据库检索中筛选出比较LCRS与传统开放手术成本效益的已发表RCT,并使用统计软件RevMan 5.3对提取的数据进行分析。7项涉及2197例患者的RCT报告了LCRS的成本效益。纳入的随机对照试验之间存在显著异质性(τ = 161,772.25,χ = 166.69,自由度 = 6,p = 0.00001,I = 96%)。在随机效应模型分析中(MD 320.37,95%CI -38.21,678.95,z = 1.75,p < 0.08),LCRS比开放性结直肠切除术成本高320.37英镑,但未达到统计学显著性,表明LCRS与开放手术的成本效益相当。LCRS是一种具有成本效益的干预措施,在有资源和专业知识的情况下,应常规提供给所有需要进行结直肠切除术的患者。

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