Arthritis and Musculoskeletal Research Group, Faculty of Health Sciences, University of Sydney, Australia.
Arthritis and Musculoskeletal Research Group, Faculty of Health Sciences, University of Sydney, Australia.
Musculoskelet Sci Pract. 2017 Aug;30:10-17. doi: 10.1016/j.msksp.2017.05.001. Epub 2017 May 2.
Functional outcome measures in clinical trials of musculoskeletal conditions need to be meaningful to individuals.
To investigate the relationship between physical performance and self/proxy-reported function in 1000 healthy children and adults.
Cross-sectional observational study (1000 Norms Project).
One thousand males and females aged 3-101 years, healthy by self-report and without major physical disability, were recruited. Twelve performance-based tests were analysed: vertical and long jump, two hand dexterity tests, four balance tests, stepping reaction time, 30-second chair stand, timed up-and-down stairs, and six-minute walk. Self/proxy-reported function was assessed using the Infant-Toddler Quality of Life questionnaire, Child Health Questionnaire, Assessment of Quality of Life (AQoL)-6D Adolescent, AQoL-8D, International Physical Activity Questionnaire and work ability question. Bivariate and multivariate correlational analyses were constructed for infants (3-4y), children (5-10y), adolescents (11-17y), adults (18-59y) and older adults (60+).
RESULTS/FINDINGS: Socio-demographic characteristics were similar to the Australian population. Among infants/children, greater jump and sit-to-stand performance correlated with higher proxy-reported function (p < 0.05). There were no significant relationships observed for adolescents (p > 0.05). Greater jump, dexterity, balance, reaction time, sit-to-stand, stair-climbing and six-minute walk performance correlated with higher self-reported function in adults (r = -0.097 to.231; p < 0.05) and older adults (r = -0.135 to 0.625; p < 0.05). Multivariate regression modelling revealed a collection of independent performance measures explaining up to 46% of the variance in self/proxy-reported function.
Many performance-based tests were significantly associated with self/proxy-reported function. We have identified a set of physical measures which could form the basis of age-appropriate functional scales for clinical trials of musculoskeletal conditions.
肌肉骨骼疾病临床试验中的功能结果测量需要对个体有意义。
研究 1000 名健康儿童和成年人的身体表现与自我/代理报告功能之间的关系。
横断面观察性研究（1000 规范项目）。
招募了 1000 名年龄在 3-101 岁、自我报告健康且没有重大身体残疾的男性和女性。分析了 12 项基于表现的测试：垂直和跳远、两项手灵巧性测试、四项平衡测试、跨步反应时间、30 秒坐站、定时上下楼梯和六分钟步行。自我/代理报告的功能使用婴儿-学步儿童生活质量问卷、儿童健康问卷、生活质量评估（AQoL）-6D 青少年版、AQoL-8D、国际体力活动问卷和工作能力问卷进行评估。为婴儿（3-4 岁）、儿童（5-10 岁）、青少年（11-17 岁）、成年人（18-59 岁）和老年人（60 岁以上）构建了双变量和多变量相关分析。
结果/发现：社会人口统计学特征与澳大利亚人口相似。在婴儿/儿童中，更大的跳跃和从坐到站的表现与更高的代理报告功能相关（p<0.05）。在青少年中没有观察到显著的关系（p>0.05）。更大的跳跃、灵巧、平衡、反应时间、从坐到站、爬楼梯和六分钟步行表现与成年人（r=-0.097 至.231；p<0.05）和老年人（r=-0.135 至 0.625；p<0.05）的自我报告功能更高相关。多元回归模型显示，一系列独立的表现测量解释了自我/代理报告功能的 46%。
许多基于表现的测试与自我/代理报告功能显著相关。我们已经确定了一组身体测量值，这些值可以作为肌肉骨骼疾病临床试验中年龄适当的功能量表的基础。
