阿片κ受体与小鼠运动条件性抑制的发展相关。

Opioid kappa receptors correlate with the development of conditioned suppression of motility in mice.

作者信息

Nabeshima T, Kamei H, Kameyama T

机构信息

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.

出版信息

Eur J Pharmacol. 1988 Jul 26;152(1-2):129-33. doi: 10.1016/0014-2999(88)90843-6.

DOI:10.1016/0014-2999(88)90843-6

PMID:2850197

Abstract

Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective kappa (non-mu) agonist. This effect of U-69,593 was antagonized by MR-2266, a kappa antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of kappa receptors may be responsible for the development of conditioned suppression of motility.

摘要

当置于先前曾接受过足部电击的相同环境中时，小鼠表现出明显的运动抑制（条件性抑制）。选择性κ（非μ）激动剂U-69,593可增强运动的条件性抑制。κ拮抗剂MR-2266可拮抗U-69,593的这种作用。此外，与U-69,593相反，单独使用MR-2266可减轻运动的条件性抑制。这些结果表明，κ受体的激活可能是运动条件性抑制形成的原因。