Tsuchiya S, Maruyama Y, Miyajima M, Koike Y, Ohta H, Katsuyama T, Kasuga Y
Division of Pathology, Nagano Cancer Center, Matsumoto, Japan.
Acta Pathol Jpn. 1988 Oct;38(10):1353-61. doi: 10.1111/j.1440-1827.1988.tb02286.x.
Bilateral breast tumors with a histologically scirrhous pattern were conclusively diagnosed as gastric carcinoma metastatic to the breast using mucosubstance histochemistry and electron microscopy. The majority of the carcinoma cells gave histochemically positive reactions for galactose oxidase-Schiff, stable class III con A, and high-iron diamine-alcian blue (HID-AB). Also electron microscopically, numerous HID-positive mucus droplets (sulfomucin) were seen in the carcinoma cells. These findings invalidated the possibility that the carcinomas were primary breast cancer. The practical applications of distinctive patterns of mucus secretion are discussed.
通过黏液物质组织化学和电子显微镜检查，最终确诊具有组织学硬癌模式的双侧乳腺肿瘤为胃癌转移至乳腺。大多数癌细胞对半乳糖氧化酶-席夫反应、稳定的III类刀豆球蛋白A以及高铁二胺-阿尔辛蓝（HID-AB）呈组织化学阳性反应。在电子显微镜下，癌细胞中也可见大量HID阳性黏液滴（硫黏液）。这些发现排除了这些癌是原发性乳腺癌的可能性。文中讨论了黏液分泌独特模式的实际应用。
