• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The actions of cyclopentane analogues of glutamic acid at binding sites for kainic and glutamic acids.

作者信息

McLennan H, Curry K

机构信息

Department of Physiology, University of British Columbia, Vancouver, Canada.

出版信息

Exp Brain Res. 1988;72(2):436-8. doi: 10.1007/BF00250265.

DOI:10.1007/BF00250265
PMID:2852118
Abstract

The actions of the four isomers of 1-amino-1, 3-cyclopentane dicarboxylate (ACPD), a conformationally restricted analogue of glutamate, have been examined for their ability to displace radiolabelled kainate and glutamate from their binding sites on membranes prepared from rat brain. All four of the isomers reduced specific kainate binding, and all enhanced that of glutamate although one (D-(-)-cis-(1R,3R)-ACPD) was significantly more active in this respect than were the other three. The results are discussed in terms of the pharmacological effects of the isomers of ACPD on single neurones and the possible structural requirements of the NMDA and kainate receptors.

摘要

相似文献

1
The actions of cyclopentane analogues of glutamic acid at binding sites for kainic and glutamic acids.
Exp Brain Res. 1988;72(2):436-8. doi: 10.1007/BF00250265.
2
Characterization of L-glutamate and kainate binding sites in the brain of a freshwater fish, Telapilia monsanbica.淡水鱼蒙桑比克细须丽鲷脑中L-谷氨酸和红藻氨酸结合位点的表征
Neuroscience. 1992 Jul;49(1):237-46. doi: 10.1016/0306-4522(92)90092-g.
3
Reassessment of [3H]glutamate binding to human brain membrane preparations.
Jpn J Pharmacol. 1991 Feb;55(2):191-6. doi: 10.1254/jjp.55.191.
4
Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors. With an appendix: diffusion of transported amino acids into brain slices.细胞摄取掩盖了L-谷氨酸对N-甲基-D-天冬氨酸受体的作用。附有附录：转运氨基酸在脑片中的扩散。
Br J Pharmacol. 1985 May;85(1):297-307. doi: 10.1111/j.1476-5381.1985.tb08860.x.
5
High-affinity kainate and domoate receptors in rat brain.
FEBS Lett. 1992 Jul 28;307(2):139-43. doi: 10.1016/0014-5793(92)80753-4.
6
A competitive inhibitor of kainic acid binding from the goldfish nervous tissue.一种来自金鱼神经组织的红藻氨酸结合竞争性抑制剂。
Brain Res. 1990 Jun 4;518(1-2):179-85. doi: 10.1016/0006-8993(90)90970-m.
7
Selective alterations in glutamate receptor subtypes after unilateral orbital enucleation.单侧眼眶摘除术后谷氨酸受体亚型的选择性改变。
Brain Res. 1991 Feb 1;540(1-2):255-65. doi: 10.1016/0006-8993(91)90515-w.
8
Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area.海马CA1区切片中谷氨酸和天冬氨酸释放的自受体调节。
J Neurochem. 1991 May;56(5):1647-55. doi: 10.1111/j.1471-4159.1991.tb02063.x.
9
L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis.L-[3H]谷氨酸与对 kainate、NMDA 和 AMPA 敏感的结合位点结合：放射自显影分析。
Brain Res. 1985 Aug 12;340(2):378-83. doi: 10.1016/0006-8993(85)90936-9.
10
Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.N-甲基-D-天冬氨酸、quisqualate和海人藻酸敏感型谷氨酸结合位点的放射自显影特征
J Pharmacol Exp Ther. 1985 Apr;233(1):254-63.

引用本文的文献

1
A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.N-甲基-D-天冬氨酸/苯环己哌啶/甘氨酸/离子通道受体大复合物的体外和体内神经化学特征综述。
Neurochem Res. 1990 Feb;15(2):217-30. doi: 10.1007/BF00972212.

本文引用的文献

1
A synthetic, conformationally restricted analogue of L-glutamic acid which acts as a powerful neuronal excitant.一种L-谷氨酸的合成、构象受限类似物，可作为一种强大的神经元兴奋剂。
Neurosci Lett. 1978 Apr;8(1):51-4. doi: 10.1016/0304-3940(78)90096-4.
2
Distinguishing characteristics between glutamate and kainic acid binding sites in brain synaptic membranes.
FEBS Lett. 1980 Aug 25;118(1):55-7. doi: 10.1016/0014-5793(80)81217-8.
3
Glutamate-containing dipeptides enhance specific binding at glutamate receptors and inhibit specific binding at kainate receptors in rat brain.含谷氨酸的二肽增强大鼠脑中谷氨酸受体的特异性结合，并抑制海人酸受体的特异性结合。
Neurosci Lett. 1984 Feb 24;44(3):281-6. doi: 10.1016/0304-3940(84)90036-3.
4
Binding sites for L-glutamate in the central nervous system of the rat.大鼠中枢神经系统中L-谷氨酸的结合位点。
Neurochem Res. 1984 Mar;9(3):393-403. doi: 10.1007/BF00963986.
5
Utilization of a cyclopentane analog of glutamate (cis-1-amino-1,3-dicarboxycyclopentane) by glutamine synthetase.
Biochemistry. 1972 Oct 24;11(22):4094-100. doi: 10.1021/bi00772a011.
6
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid.神经元兴奋剂1-氨基-1,3-环戊烷二羧酸异构体的合成、拆分及绝对构型
J Med Chem. 1988 Apr;31(4):864-7. doi: 10.1021/jm00399a030.
7
Excitation of rat hippocampal neurones by the stereoisomers of cis- and trans-1-amino-1,3-cyclopentane dicarboxylate.
Can J Physiol Pharmacol. 1987 Nov;65(11):2196-201. doi: 10.1139/y87-347.
8
Identification and characterization of an N-methyl-D-aspartate-specific L-[3H]glutamate recognition site in synaptic plasma membranes.
J Neurochem. 1987 Jun;48(6):1699-708. doi: 10.1111/j.1471-4159.1987.tb05726.x.
9
L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis.L-[3H]谷氨酸与对 kainate、NMDA 和 AMPA 敏感的结合位点结合：放射自显影分析。
Brain Res. 1985 Aug 12;340(2):378-83. doi: 10.1016/0006-8993(85)90936-9.
10
The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons.N-甲基-D-天冬氨酸受体与海马体CA1区锥体神经元的爆发式放电
Neuroscience. 1987 Aug;22(2):563-71. doi: 10.1016/0306-4522(87)90353-8.