福司可林对“体外”胃酸分泌的影响：与不同促分泌剂的相互作用。

Effect of forskolin on gastric acid secretion "in vitro": interaction with different secretagogues.

Coruzzi G, Adami M, Bertaccini G

Institute of Pharmacology, University of Parma, Italy.

Gen Pharmacol. 1988;19(6):767-70.

Abstract

The effect of forskolin has been evaluated in the isolated gastric fundus from immature rats in comparison with other secretagogues. 2. Forskolin (10 nM-1 microM) caused an increase in acid production being more potent than histamine, dimaprit, bethanechol and DBcAMP and equipotent with pentagastrin and isoprenaline. 3. The response to forskolin was unaffected by ranitidine (1 microM), atropine (10 nM) and PGE1 (10 microM); conversely it was inhibited by omeprazole (3 microM). 4. Threshold concentration of forskolin (30 nM) enhanced the response to histamine, dimaprit and isoprenaline but not that to bethanechol and DBcAMP. 5. The above data confirm the strong gastric secretory activity of forskolin even in the early stage of development.

摘要

与其他促分泌剂相比，已在未成熟大鼠的离体胃底中评估了福斯高林的作用。2. 福斯高林（10 nM - 1 μM）可引起胃酸分泌增加，其效力比组胺、二甲双胍、氨甲酰甲胆碱和二丁酰环磷腺苷更显著，与五肽胃泌素和异丙肾上腺素相当。3. 雷尼替丁（1 μM）、阿托品（10 nM）和前列腺素E1（10 μM）对福斯高林的反应无影响；相反，奥美拉唑（3 μM）可抑制该反应。4. 福斯高林的阈浓度（30 nM）增强了对组胺、二甲双胍和异丙肾上腺素的反应，但对氨甲酰甲胆碱和二丁酰环磷腺苷的反应无增强作用。5. 上述数据证实了福斯高林即使在发育早期也具有强大的胃分泌活性。