Aberdeen Fungal Group, MRC Centre for Medical Mycology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Institute of Medical Sciences, Foresterhill, United Kingdom.
Aberdeen Fungal Group, MRC Centre for Medical Mycology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Institute of Medical Sciences, Foresterhill, United Kingdom.
Adv Microb Physiol. 2017;70:85-103. doi: 10.1016/bs.ampbs.2017.01.006. Epub 2017 Feb 16.
All living organisms require certain micronutrients such as iron, zinc, manganese and copper for cellular function and growth. For human pathogens however, the maintenance of metal ion homeostasis is particularly challenging. This is because the mammalian host actively enforces extremes of micronutrient availability on potential microbial invaders-processes collectively termed nutritional immunity. The role of iron sequestration in controlling microbial infections is well established and, more recently, the importance of other metals including zinc, manganese and copper has been recognised. In this chapter, we explore the nutritional immune mechanisms that defend the human body against fungal infections and the strategies that these important pathogens exploit to counteract nutritional immunity and thrive in the infected host.
所有生物体都需要某些微量元素，如铁、锌、锰和铜，以维持细胞功能和生长。然而，对于人类病原体来说，维持金属离子的内环境稳定是特别具有挑战性的。这是因为哺乳动物宿主积极地对潜在的微生物入侵者施加微量元素可用性的极端条件——这些过程统称为营养免疫。铁螯合在控制微生物感染中的作用已得到充分证实，最近，锌、锰和铜等其他金属的重要性也得到了认可。在本章中，我们探讨了防御人体真菌感染的营养免疫机制，以及这些重要病原体用来对抗营养免疫并在感染宿主中茁壮成长的策略。
