顺铂胸腔内热化疗治疗伴有胸膜转移的卵巢癌

Jun Su Youn, Seok Yang Ki, Kato Tomoyasu, Chun Da Som, Lee Yoon Hee, Chong Gun Oh, Lee Yoon Soon, Cho Young Lae, Hong Dae Gy

Department of Obstetrics and Gynecology, Kyungpook National University Medical Center, Daegu, Korea.

Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Medical Center, Daegu, Korea.

Obstet Gynecol Sci. 2017 May;60(3):308-313. doi: 10.5468/ogs.2017.60.3.308. Epub 2017 May 15.

Intrathoracic metastasis of ovarian cancer has poor prognosis regardless of treatment modality. Recent development of surgical techniques and the new concept of direct infusion of chemotherapeutic agents with hyperthermia could help with the treatment of disseminated diseases in ovarian cancer. Using video-assisted thoracoscopic surgery and intracavitary chemotherapy with hyperthermia, we tried hyperthermic intrathoracic chemotherapy for a case of stage IV high-grade serous ovarian cancer with pleural metastasis. There was no high-grade complication related to the procedure. The patient is alive without disease at 32 months after initial treatment.

无论采用何种治疗方式，卵巢癌的胸内转移预后都很差。外科技术的最新发展以及化疗药物热灌注的新概念可能有助于治疗卵巢癌的播散性疾病。我们采用电视辅助胸腔镜手术和腔内热化疗，对1例伴有胸膜转移的IV期高级别浆液性卵巢癌患者尝试进行胸腔内热化疗。该手术未出现严重并发症。患者在初始治疗后32个月仍存活且无疾病复发。