Angiogenesis &Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Ludwigstr. 43, D-61231 Bad Nauheim, Germany.
International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland.
Nat Rev Mol Cell Biol. 2017 Aug;18(8):477-494. doi: 10.1038/nrm.2017.36. Epub 2017 May 24.
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it supplies. Whereas the general mechanisms of blood and lymphatic vessel development are being defined with increasing molecular precision, studies of the processes of endothelial specialization remain mostly descriptive. Recent insights from genetic animal models illuminate how endothelial cells interact with each other and with their tissue environment, providing paradigms for vessel type- and organ-specific endothelial differentiation. Delineating these governing principles will be crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.
血液和淋巴管遍布几乎所有的身体组织，并在生理学和疾病中有许多重要作用。这些网络的内层由单层内皮细胞组成，根据其供应的组织的需要而专门化。虽然血液和淋巴管发育的一般机制正在以越来越高的分子精度来定义，但内皮细胞特化过程的研究仍然主要是描述性的。遗传动物模型的最新研究结果阐明了内皮细胞如何相互作用以及与它们的组织环境相互作用，为血管类型和器官特异性内皮细胞分化提供了范例。阐明这些控制原则对于理解组织的发育和维持以及它们的功能如何在疾病中变得异常至关重要。
