Department of Cardiology, Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing, China.
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Am J Hypertens. 2017 Oct 1;30(10):1024-1031. doi: 10.1093/ajh/hpx089.
Animal researches reported that the dysfunction of profilin1 (PFN1) was involved in the physiological arterial stiffness and vascular remodeling linking to the etiology of hypertension (HT). This study mainly aims at evaluating the association of PFN1 and HT in a Han Chinese population.
A case-control study consisted of 2,012 HT cases and 2,210 controls was conducted and 2,116 participants from the healthy controls were further followed up for average 5.01 years. Logistic and Cox regression models were applied to evaluate the association of 4 tag single nucleotide polymorphisms (SNPs) of PFN1 and ENO3 with HT.
There was no significant association of the 4 SNPs between HT cases and controls even after adjustment for confounding factors (P > 0.05). Haplotype analysis did not identify any significant haplotype with HT. There were no statistical difference of systolic blood pressure (BP) and diastolic BP among different genotypes in antihypertensive-treated group and untreated group. In follow-up population, there was no significant association of candidate SNPs with HT even after adjustment for covariates (all P > 0.05). Of note, the plasma profilin1 level of HT cases was significantly higher than that of control subjects (P = 0.011). The profilin1 levels of controls significantly decreased with variation of rs238243 at PFN1 (P = 0.041), and the profilin1 levels of HT cases increased with variation of rs238238 at ENO3 (P = 0.004).
Our results suggest that HT cases displayed an elevated plasma profilin1. Variants of rs238243 and rs238238 might regulate profilin1 expression by epigenetic modification and indirectly affects the susceptible threshold of HT.
动物研究报告称，丝状肌动蛋白结合蛋白 1（PFN1）功能障碍与生理动脉僵硬和血管重塑有关，而这些变化与高血压（HT）的病因有关。本研究主要旨在评估汉族人群中 PFN1 与 HT 的相关性。
进行了一项病例对照研究，共纳入 2012 例 HT 病例和 2210 例对照，其中 2116 例健康对照进一步随访平均 5.01 年。采用 logistic 和 Cox 回归模型评估 PFN1 和 ENO3 的 4 个标签单核苷酸多态性（SNP）与 HT 的相关性。
即使在调整混杂因素后，HT 病例与对照组之间的 4 个 SNP 之间也没有显著相关性（P > 0.05）。单体型分析也未发现与 HT 相关的显著单体型。在降压治疗组和未治疗组中，不同基因型之间的收缩压（BP）和舒张压（DBP）没有统计学差异。在随访人群中，即使在调整协变量后，候选 SNP 与 HT 之间也没有显著相关性（均 P > 0.05）。值得注意的是，HT 病例的血浆丝状肌动蛋白结合蛋白 1 水平明显高于对照组（P = 0.011）。随着 PFN1 中 rs238243 的变化，对照组的丝状肌动蛋白结合蛋白 1 水平显著降低（P = 0.041），而 ENO3 中 rs238238 的变化导致 HT 病例的丝状肌动蛋白结合蛋白 1 水平升高（P = 0.004）。
我们的研究结果表明，HT 病例表现出升高的血浆丝状肌动蛋白结合蛋白 1。rs238243 和 rs238238 变体可能通过表观遗传修饰调节丝状肌动蛋白结合蛋白 1 的表达，并间接影响 HT 的易感性阈值。
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