Scallan Elizabeth M, Sample Saundra H, Beierschmitt Amy M, Palmour Roberta M
Department of Clinical Sciences, Ross University School of Veterinary Medicine, St. Kitts, Eastern Caribbean.
Department of Biomedical Sciences, Ross University School of Veterinary Medicine, St. Kitts, Eastern Caribbean.
Vet Clin Pathol. 2017 Sep;46(3):430-435. doi: 10.1111/vcp.12505. Epub 2017 May 19.
Established RIs for geriatric African Green monkeys (Chlorocebus aethiops sabaeus) are critical for clinical differentiation of normal aging from disease-related changes in this population.
The aim of this study was to establish hematologic and serum biochemical RIs for a Caribbean captive population of geriatric (≥ 15 years of age) African Green monkeys, or Vervets.
Inclusion and exclusion criteria were defined for a cohort of 109 healthy, aged (15- to 30-year-old, median 19-year-old) Vervets. Both male (34) and female (75) monkeys were included in RI generation. Complete manual and analyzer-generated blood counts and serum biochemistry profiles were performed at Ross University School of Veterinary Medicine, West Farm, St. Kitts, West Indies. All results were evaluated using Reference Value Advisor. Isolated outliers were identified using Dixon's outlier range statistic and not included in determination of RIs for individual analytes. Reference intervals were determined using parametric and nonparametric methods depending on the distribution. Data, including mean, median, maximum, and minimum values, were tabulated.
Of the 109 animals, 12 monkeys were excluded due to abnormal physical examination results (2 monkeys), and ≥ 2 confirmed outliers (9 monkeys), or evidence of disease based on laboratory data (one monkey).
This study provides useful RIs for assessment of hematology and serum biochemical variables in a geriatric population of African Green monkeys in the Caribbean.
确定老年非洲绿猴（Chlorocebus aethiops sabaeus）的参考区间对于临床区分该群体正常衰老与疾病相关变化至关重要。
本研究的目的是为加勒比地区圈养的老年（≥15岁）非洲绿猴（即绿长尾猴）群体建立血液学和血清生化参考区间。
为109只健康的老年（15至30岁，中位年龄19岁）绿长尾猴队列定义了纳入和排除标准。参考区间生成纳入了雄性（34只）和雌性（75只）猴子。在西印度群岛圣基茨岛西农场的罗斯大学兽医学院进行了完整的手工和分析仪生成的血细胞计数及血清生化分析。所有结果均使用参考值顾问进行评估。使用狄克逊异常值范围统计量识别孤立的异常值，且不将其纳入单个分析物参考区间的确定。根据分布情况使用参数和非参数方法确定参考区间。将包括均值、中位数、最大值和最小值的数据制成表格。
109只动物中，12只猴子因体格检查结果异常（2只猴子）、≥2个已确认的异常值（9只猴子）或基于实验室数据的疾病证据（1只猴子）而被排除。
本研究为评估加勒比地区老年非洲绿猴群体的血液学和血清生化变量提供了有用的参考区间。
