血浆血清素水平是结直肠癌患者复发和预后不良的一个预测指标。
Plasma serotonin level is a predictor for recurrence and poor prognosis in colorectal cancer patients.
作者信息
Xia Yan, Wang Dawei, Zhang Nan, Wang Zhihao, Pang Li
机构信息
Department of Gastroenterology, The First Hospital of Jilin University, Changchun, China.
Department of Emergency, The First Hospital of Jilin University, Changchun, China.
出版信息
J Clin Lab Anal. 2018 Feb;32(2). doi: 10.1002/jcla.22263. Epub 2017 May 22.
AIM
To investigate the prognostic value of plasma serotonin levels in colorectal cancer (CRC).
PATIENTS AND METHODS
Preoperative plasma serotonin levels of 150 healthy control (HC) cases, 150 benign colorectal polyp (BCP) cases, and 176 CRC cases were determined using radioimmunoassay assay. Serotonin levels were compared between HC, BCP, and CRC cases, and those in CRC patients were related to 5-year outcome.
RESULTS
Plasma serotonin levels were markedly higher in CRC patients than in either HCs or BCP cases. An elevated serotonin level was significantly associated with advanced tumor node metastasis. Receiver operating characteristic curve analysis showed that the level of serotonin had a high predictive value for disease recurrence and mortality. Multivariate analysis revealed that high serotonin level was significantly associated with poor recurrence-free survival and overall survival.
CONCLUSION
Our results suggest that a high peri-operative plasma serotonin level is useful as a prognostic biomarker for CRC recurrence and poor survival.
目的
探讨血浆血清素水平在结直肠癌（CRC）中的预后价值。
患者与方法
采用放射免疫分析法测定150例健康对照（HC）、150例大肠良性息肉（BCP）及176例CRC患者术前血浆血清素水平。比较HC、BCP和CRC患者的血清素水平，并分析CRC患者血清素水平与5年预后的关系。
结果
CRC患者血浆血清素水平显著高于HC或BCP患者。血清素水平升高与肿瘤淋巴结转移进展显著相关。受试者工作特征曲线分析表明，血清素水平对疾病复发和死亡率具有较高的预测价值。多因素分析显示，高血清素水平与无复发生存期和总生存期较差显著相关。
结论
我们的结果表明，围手术期血浆血清素水平升高可作为CRC复发和不良生存的预后生物标志物。
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