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推动医疗保健领域的精准医学:应对实施挑战以增加临床环境中的药物遗传学检测。

Advancing precision medicine in healthcare: addressing implementation challenges to increase pharmacogenetic testing in the clinical setting.

作者信息

Dong Olivia M, Wiltshire Tim

机构信息

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, and Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, and Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

出版信息

Physiol Genomics. 2017 Jul 1;49(7):346-354. doi: 10.1152/physiolgenomics.00029.2017. Epub 2017 May 26.

Abstract

The incorporation of precision medicine into the clinical setting is becoming increasingly feasible with the availability of more affordable genetic sequencing technologies and successful genetic associations with phenotypes, especially in the pharmacogenomic field. Although substantial progress has been made to ensure successful uptake of pharmacogenomic testing in the clinical setting already, many challenges still remain for sustainable implementation. The importance of pharmacogenomic information in patient care, identifying key barriers, and proposed solutions for advancing pharmacogenomic implementation will be discussed.

摘要

随着更经济实惠的基因测序技术的出现以及基因与表型的成功关联,尤其是在药物基因组学领域,将精准医学纳入临床实践变得越来越可行。尽管在确保临床环境中成功采用药物基因组学检测方面已经取得了重大进展,但在可持续实施方面仍存在许多挑战。本文将讨论药物基因组学信息在患者护理中的重要性、识别关键障碍以及推进药物基因组学实施的建议解决方案。

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