Zhang L, Wu N, Li M, Sun W, Lyu L, Hou D H, Lin D M
Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Department of Pathology, Beijing Cancer Hospital, Beijing 100036, China.
Zhonghua Zhong Liu Za Zhi. 2017 Apr 23;39(4):269-273. doi: 10.3760/cma.j.issn.0253-3766.2017.04.006.
To investigate the correlation between Ground Glass Opacity (GGO) component proportion and quantitative classification of lepidic growth pattern in pathological stage Ⅰpulmonary adenocarcinoma. Pathological and HRCT data of 183 stage Ⅰ invasive adenocarcinoma patients from January 2005 to December 2012 were retrospectively reviewed. The proportion of GGO was calculated from diameter and volume.The correlation between GGO component proportion and lepidic growth pattern in pathological were analyzed by Spearman correlation. Among 183 patients, the proportion of GGO component calculated by maximum diameter method and three-dimensional computerized quantification was 0.43±0.35 and 0.20±0.18, respectively. The percentage of lepidic growth pattern component using semi-quantitative analysis of pathological sections was 0.29±0.25.The proportion of GGO by diameter and three-dimensional computerized quantification was significantly correlated with the percentage of lepidic growth pattern component (=0.599, < 0.001; =0.620, <0.001). There was a positive correlation between the content of lepidic growth pattern and the content of GGO in the small adenocarcinoma. Three-dimensional computerized quantification was a better method in preoperational evaluation.
探讨Ⅰ期肺腺癌病理中磨玻璃影（GGO）成分比例与贴壁生长模式定量分类之间的相关性。回顾性分析2005年1月至2012年12月期间183例Ⅰ期浸润性腺癌患者的病理及高分辨率CT（HRCT）数据。根据直径和体积计算GGO的比例。采用Spearman相关性分析GGO成分比例与病理中贴壁生长模式之间的相关性。183例患者中，通过最大直径法和三维计算机定量计算的GGO成分比例分别为0.43±0.35和0.20±0.18。采用病理切片半定量分析的贴壁生长模式成分百分比为0.29±0.25。通过直径和三维计算机定量计算的GGO比例与贴壁生长模式成分百分比显著相关（=0.599，<0.001；=0.620，<0.001）。小腺癌中贴壁生长模式的含量与GGO的含量呈正相关。三维计算机定量在术前评估中是一种更好的方法。
Zotero 插件