Nishijima Toshimitsu, Yamamoto Hidetaka, Nakano Takafumi, Hatanaka Yui, Taguchi Ken-Ichi, Masuda Muneyuki, Oda Yoshinao
Department of Anatomic Pathology, Graduate of School of Medical Science, Kyushu University, Fukuoka, Japan.
Department of Anatomic Pathology, Graduate of School of Medical Science, Kyushu University, Fukuoka, Japan.
Pathol Res Pract. 2017 Jun;213(6):706-709. doi: 10.1016/j.prp.2017.02.019. Epub 2017 Feb 28.
We report a rare case of low-grade intraductal carcinoma with tumor-associated lymphoid proliferation (TALP) in the parotid gland of a 75-year-old woman. Grossly, the tumor was solid and cystic. Histologically, the tumor consisted of a papillary-cystic, micropapillary, or focally cribriform proliferations of epithelial cells with low-grade cytological atypia. The interspaces between the epithelial components were filled with prominent lymphoid stroma and lymphoid follicles, superficially mimicking Warthin tumor. The neoplastic epithelial cells were positive for S100 protein by immunohistochemical staining. There was an attenuated layer of myoepithelial cells all around the epithelial components, indicating a non-invasive (in situ) nature. Although TALP is a rare finding in intraductal carcinoma, it should be considered as a histological variation of this kind of tumor. The relationship between intraductal carcinoma, low-grade cribriform cystadenocarcinoma, low-grade salivary duct carcinoma, and salivary duct carcinoma in situ is also discussed in this report.
我们报告了一例罕见的75岁女性腮腺低度导管内癌伴肿瘤相关淋巴样增生（TALP）的病例。大体上，肿瘤为实性和囊性。组织学上，肿瘤由具有低度细胞学异型性的上皮细胞呈乳头状囊性、微乳头状或局灶筛状增生构成。上皮成分之间的间隙充满显著的淋巴样间质和淋巴滤泡，表面上类似沃辛瘤。免疫组化染色显示肿瘤性上皮细胞S100蛋白阳性。上皮成分周围有一层变薄的肌上皮细胞层，提示为非浸润性（原位）性质。尽管TALP在导管内癌中是罕见发现，但应将其视为这类肿瘤的一种组织学变异。本报告还讨论了导管内癌、低度筛状囊腺癌、低度涎腺导管癌和原位涎腺导管癌之间的关系。
