Younas Mehwish, Psomas Christina, Mehraj Vikram, Cezar Renaud, Portales Pierre, Tuaillon Edouard, Guigues Adeline, Reynes Jacques, Corbeau Pierre, Routy Jean-Pierre
Institute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France.
Infectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier cedex 5, France.
Open AIDS J. 2017 Apr 26;11:32-35. doi: 10.2174/1874613601711010032. eCollection 2017.
Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease.
Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation.
Here we show that it is not the case in patients with suppressed viremia. Thus, IL-33 plays its alarmin role only during the early phase of the infection.
白细胞介素-33（IL-33）是一种细胞损伤诱导的警报素。肿瘤抑制素（sST2）是IL-33产生的替代标志物，其血浆浓度是心血管疾病的预后标志物。
最近，我们报道在早期HIV-1感染中sST2血浆水平升高，并与微生物易位和T细胞活化标志物相关。
在此我们表明，病毒血症得到抑制的患者并非如此。因此，IL-33仅在感染的早期阶段发挥其警报素作用。
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