化妆品中使用的氨基酸烷基酰胺的安全性评估。

Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics.

作者信息

Burnett Christina L, Heldreth Bart, Bergfeld Wilma F, Belsito Donald V, Hill Ronald A, Klaassen Curtis D, Liebler Daniel C, Marks James G, Shank Ronald C, Slaga Thomas J, Snyder Paul W, Andersen F Alan

机构信息

1 Cosmetic Ingredient Review Scientific Analyst/Writer, Cosmetic Ingredient Review, Washington, DC, USA.

2 Cosmetic Ingredient Review Chemist, Cosmetic Ingredient Review, Washington, DC, USA.

出版信息

Int J Toxicol. 2017 May/Jun;36(1_suppl):17S-56S. doi: 10.1177/1091581816686048.

DOI:10.1177/1091581816686048

PMID:28553738

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the product use, formulation, and safety data of 115 amino acid alkyl amides, which function as skin and hair conditioning agents and as surfactants-cleansing agents in personal care products. Safety test data on dermal irritation and sensitization for the ingredients with the highest use concentrations, lauroyl lysine and sodium lauroyl glutamate, were reviewed and determined to adequately support the safe use of the ingredients in this report. The Panel concluded that amino acid alkyl amides are safe in the present practices of use and concentration in cosmetics, when formulated to be nonirritating.

摘要

化妆品成分审查专家小组（该小组）审查了115种氨基酸烷基酰胺的产品用途、配方和安全数据，这些氨基酸烷基酰胺在个人护理产品中用作皮肤和头发调理剂以及表面活性剂清洁剂。审查了使用浓度最高的成分月桂酰赖氨酸和月桂酰谷氨酸钠的皮肤刺激和致敏安全性测试数据，并确定这些数据足以支持本报告中这些成分的安全使用。该小组得出结论，当配方设计为无刺激性时，氨基酸烷基酰胺在化妆品目前的使用方法和浓度下是安全的。