Starinieri Pascal, Declercq Peter E, Robic Boris, Yilmaz Alaaddin, Van Tornout Michiel, Dubois Jasperina, Mees Urbain, Hendrikx Marc
1 Department of Clinical Perfusion, Jessa Hospital, Belgium.
2 Department of Laboratory Medicine, Jessa Hospital, Belgium.
Perfusion. 2017 Jul;32(5):403-408. doi: 10.1177/0267659117691814. Epub 2017 Feb 1.
Even though results have been encouraging, an unequivocal conclusion on the beneficial effect of minimally invasive extracorporeal circulation (MiECC) in patients undergoing aortic valve surgery cannot be derived from previous publications. Long-term outcomes are rarely reported and a significant decrease in operative mortality has not been shown. Most studies have a limited number of patients and are underpowered. They merely report on short-term results of a heterogeneous intraoperative group using different types of ECC system in aortic valve surgery. The aim of the present study was to determine whether MiECC systems are more beneficial than conventional extracorporeal systems (CECC) with regard to mortality, hospital stay and inflammation and with only haemodilution and blood-air interface as differences.
We retrospectively analysed data regarding mortality, hospital stay and inflammation in patients undergoing isolated aortic valve surgery. Forty patients were divided into two groups based on the type of extracorporeal system used; conventional (n=20) or MiECC (n=20).
Perioperative blood product requirements were significantly lower in the MiECC group (MiECC: 0.2±0.5 units vs CECC: 0.9±1.2 units, p=0.004). No differences were seen postoperatively regarding mortality (5% vs 5%, p=0.99), total length of hospital stay (10.6±7.2 days (MiECC) vs 12.1±5.9 days (CECC), p=0.39) or inflammation markers (CRP: MiECC: 7.09±13.62 mg/L vs CECC: 3.4±3.2 mg/L, p=0.89).
MiECC provides circulatory support that is equally safe and feasible as conventional extracorporeal circuits. No differences in mortality, hospital stay or inflammation markers were observed.
尽管已有研究结果令人鼓舞,但以往的文献仍无法就微创体外循环(MiECC)对接受主动脉瓣手术患者的有益效果得出明确结论。长期预后鲜有报道,且未显示手术死亡率有显著降低。大多数研究的患者数量有限,效能不足。它们仅报告了在主动脉瓣手术中使用不同类型体外循环系统的异质术中组的短期结果。本研究的目的是确定MiECC系统在死亡率、住院时间和炎症方面是否比传统体外循环系统(CECC)更具优势,且仅以血液稀释和血-气界面作为差异因素。
我们回顾性分析了接受单纯主动脉瓣手术患者的死亡率、住院时间和炎症数据。根据所使用的体外循环系统类型,将40例患者分为两组;传统组(n = 20)或MiECC组(n = 20)。
MiECC组围手术期血液制品需求量显著更低(MiECC:0.2±0.5单位 vs CECC:0.9±1.2单位,p = 0.004)。术后在死亡率(5% vs 5%,p = 0.99)、总住院时间(MiECC组为10.6±7.2天 vs CECC组为12.1±5.9天,p = 0.39)或炎症标志物方面未见差异(CRP:MiECC组为7.09±13.62 mg/L vs CECC组为3.4±3.2 mg/L,p = 0.89)。
MiECC提供的循环支持与传统体外循环同样安全可行。在死亡率、住院时间或炎症标志物方面未观察到差异。