Saraggi Deborah, Salmaso Roberto, Valentini Elisa, Munari Giada, Vindigni Vincenzo, Rugge Massimo, Fassan Matteo, Cerroni Lorenzo
Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy; Clinic of Plastic and Reconstructive Surgery, University of Padua, Padua, Italy.
Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
Pathol Res Pract. 2017 Jul;213(7):860-862. doi: 10.1016/j.prp.2017.03.012. Epub 2017 Mar 30.
A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. These data support a common molecular landscape of the two lesions.
一名40岁女性，头皮上一个先前存在的淡黄色疣状斑块上出现了一个色素性结节。组织学诊断为皮脂腺痣（SN）内发生的色素性毛母细胞瘤。对BRAF、NRAS、HRAS和KRAS基因进行了多基因热点突变分析，发现在毛母细胞瘤和皮脂腺痣成分中均存在共同的G13R HRAS突变。这些数据支持了这两种病变的共同分子格局。
