皮脂腺痣中发生的色素性毛母细胞瘤：HRAS 突变作为常见的分子驱动因素。
Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver.
作者信息
Saraggi Deborah, Salmaso Roberto, Valentini Elisa, Munari Giada, Vindigni Vincenzo, Rugge Massimo, Fassan Matteo, Cerroni Lorenzo
机构信息
Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy; Clinic of Plastic and Reconstructive Surgery, University of Padua, Padua, Italy.
Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
出版信息
Pathol Res Pract. 2017 Jul;213(7):860-862. doi: 10.1016/j.prp.2017.03.012. Epub 2017 Mar 30.
A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. These data support a common molecular landscape of the two lesions.
一名40岁女性，头皮上一个先前存在的淡黄色疣状斑块上出现了一个色素性结节。组织学诊断为皮脂腺痣（SN）内发生的色素性毛母细胞瘤。对BRAF、NRAS、HRAS和KRAS基因进行了多基因热点突变分析，发现在毛母细胞瘤和皮脂腺痣成分中均存在共同的G13R HRAS突变。这些数据支持了这两种病变的共同分子格局。
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