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重度肥胖孕妇阻塞性睡眠呼吸暂停的筛查方法

Screening methods for obstructive sleep apnoea in severely obese pregnant women.

作者信息

Longworth H, McCallin K, Narayanan R P, Turner M A, Quenby S, Rycroft D, Charnley M, Abayomi J, Topping J, Weeks A D, Wilding J P H

机构信息

Liverpool Women's NHS Foundation Trust, Liverpool, UK.

School of Medical Education, University of Liverpool, Liverpool, UK.

出版信息

Clin Obes. 2017 Aug;7(4):239-244. doi: 10.1111/cob.12196. Epub 2017 May 29.

Abstract

Obstructive sleep apnoea (OSA) is an often-overlooked diagnosis, more prevalent in the obese population. Screening method accuracy, uptake and hence diagnosis is variable. There is limited data available regarding the obese pregnant population; however, many studies highlight potential risks of apnoeic episodes to mother and foetus, including hypertension, diabetes and preeclampsia. A total of 162 women with a body mass index (BMI) ≥ 35 were recruited from a tertiary referral hospital in the northwest of England. They were invited to attend three research antenatal clinics, completing an Epworth Sleepiness Scale (ESS) questionnaire at each visit. A monitor measuring the apnoea hypopnoea index (AHI) was offered at the second visit. Data taken from consent forms, hospital notes and hospital computer records were collated and anonymized prior to statistical analysis. A total of 12.1% of women had an ESS score of >10, suggesting possible OSA. Rates increased throughout pregnancy, although unfortunately, the attrition rate was high; 29.0% of women used the RUSleeping (RUS) meter, and only one (2.1%) met pre-specified criteria for OSA (AHI ≥ 15). This individual had OSA categorized as severe and underwent investigations for preeclampsia, eventually delivering by emergency caesarean section due to foetal distress. The accuracy of the ESS questionnaire, particularly the RUS monitor, to screen for OSA in the pregnant population remains unclear. Further research on a larger sample size using more user-friendly technology to confidently measure AHI would be beneficial. There are currently no guidelines regarding screening for OSA in the obese pregnant population, yet risks to both mother and foetus are well researched.

摘要

阻塞性睡眠呼吸暂停(OSA)是一种常被忽视的诊断,在肥胖人群中更为普遍。筛查方法的准确性、接受度以及由此导致的诊断情况各不相同。关于肥胖孕妇群体的数据有限;然而,许多研究强调了呼吸暂停发作对母亲和胎儿的潜在风险,包括高血压、糖尿病和先兆子痫。从英格兰西北部的一家三级转诊医院招募了162名体重指数(BMI)≥35的女性。她们被邀请参加三次产前研究门诊,每次就诊时填写一份爱泼华嗜睡量表(ESS)问卷。在第二次就诊时提供了一个测量呼吸暂停低通气指数(AHI)的监测仪。在进行统计分析之前,对从同意书、医院病历和医院计算机记录中获取的数据进行了整理和匿名处理。共有12.1%的女性ESS评分>10,提示可能患有OSA。患病率在整个孕期有所上升,不过遗憾的是,流失率很高;29.0%的女性使用了RUSleeping(RUS)监测仪,只有一名女性(2.1%)符合OSA的预先设定标准(AHI≥15)。该个体的OSA被归类为重度,并接受了先兆子痫的检查,最终因胎儿窘迫行急诊剖宫产。ESS问卷,尤其是RUS监测仪,在孕妇群体中筛查OSA的准确性仍不明确。使用更便于用户操作的技术对更大样本量进行进一步研究,以可靠地测量AHI,将是有益的。目前尚无关于肥胖孕妇群体中OSA筛查的指南,然而对母亲和胎儿的风险已有充分研究。

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