结直肠癌肝转移中的肿瘤退缩分级、K-RAS 突变情况及 c-MET

Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases.

作者信息

Lorenzon Laura, Ricca Luana, Pilozzi Emanuela, Lemoine Antoinette, Riggio Valentina, Giudice Maria Teresa, Mallel Giuseppe, Fochetti Flavio, Balducci Genoveffa

机构信息

Surgical and Medical Department of Traslational Medicine, University of Rome "La Sapienza", Sant'Andrea Hospital of Rome, Italy.

Surgical and Medical Department of Traslational Medicine, University of Rome "La Sapienza", Sant'Andrea Hospital of Rome, Italy; AP-HP Hôpital Paul Brousse, Biochimie et Oncogénétique, Villejuif, 94800, France.

出版信息

Pathol Res Pract. 2017 Aug;213(8):1002-1009. doi: 10.1016/j.prp.2017.04.013. Epub 2017 Apr 21.

DOI:10.1016/j.prp.2017.04.013

PMID:28559118

Abstract

INTRODUCTION

Recently TRG, necrosis grade and the rate of viable cancer cells of colorectal liver metastases were correlated with the response to chemotherapy treatments, whereas K-RAS mutations and c-MET over-expression were correlated with the prognosis.

METHODS

58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly. We investigated the K-RAS mutational profile, the c-MET over-expression along with patients' survivals curves.

RESULTS

Patients undergone neo-adjuvant treatment presented significant higher fibrosis rates and lower rates of viable cells. 36.7% of the patients had a K-RAS mutation and the 26.7% presented c-MET over-expression, but these features did not correlate with patients' clinical/pathological data. Survival analysis documented that K-RAS WT patients presenting c-MET over-expression had worse outcomes.

CONCLUSION

Fibrosis and the rate of viable cells significantly correlate with the response to chemotherapy treatments. c-MET is a promising marker in K-RAS WT patients.

摘要