Britten Hugh B
Biological Resources Research Center, Department of Biology, University of Nevada, Reno, Nevada, 89557.
Evolution. 1996 Dec;50(6):2158-2164. doi: 10.1111/j.1558-5646.1996.tb03606.x.
Meta-analyses of published correlation coefficients between multilocus heterozygosity (MLH) and two fitness surrogates, growth rate and fluctuating asymmetry, suggested that the strength of these correlations are generally weak. A variety of plants and animals was included in the meta-analyses. A statistically homogeneous group of MLH-growth rate correlation coefficients that included both plants and animals yielded a common correlation of r = 0.133. A common correlation of r = -0.170 was estimated for correlations between MLH and fluctuating asymmetry in three species of salmonid fishes. These results suggest that selection, including overdominance, has at most a weak effect at allozyme loci and cast some doubt on the widely held notion that heterozygosity and individual fitness are strongly correlated.
对已发表的多位点杂合性（MLH）与两个适合度替代指标（生长率和波动不对称性）之间相关系数的荟萃分析表明，这些相关性的强度通常较弱。荟萃分析纳入了多种动植物。一个包括植物和动物的统计上同质的MLH-生长率相关系数组得出的共同相关系数r = 0.133。对于三种鲑科鱼类中MLH与波动不对称性之间的相关性，估计共同相关系数r = -0.170。这些结果表明，包括超显性在内的选择在等位酶位点上至多具有微弱的影响，并对杂合性与个体适合度密切相关这一广泛持有的观念提出了一些质疑。
